THE DROSOPHILA GENETICS AND RNAI CORE (THE FLY CORE)

果蝇遗传学和 RNAI 核心（果蝇核心）

• 批准号: 8143197
• 负责人: PATRICIA K DONAHOE
• 金额: $ 4.75万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8143197
• 关键词: Biological Models; Congenital Abnormality; Development; Diaphragmatic Hernia; Disease; Drosophila genus; Drosophila melanogaster; Gene Mutation; Genes; Genetic; Genomics; Human; Knowledge; Lesion; Malignant Neoplasms; Metabolic Diseases; Molecular; Outcome; Pathway interactions; Process; RNA Interference; Research; Research Personnel; Resources; Signal Pathway; Structure; Systems Biology; Translational Research; Work; abstracting; design; fly; insight; interest; programs

Drosophila Core's overall objectives and Abstract Over 100 years of research has established the common fruit fly, Drosophila melanogaster, as a premier model system. As translational research, systems biology and genomics come of age, researchers are increasingly turning to more simple model systems to gain insights into the molecular mechanisms and phenotypic outcomes of genetic lesions in their particular genes of interest. To date, 60% of disease related genes in humans have conserved counterparts in flies. Further, virtually all of the signaling pathways implicated in cancer, metabolic diseases, and congenital birth defects are conserved in flies. The Drosophila Genetics and RNAi Core, designed to serve this program project, allows researchers the opportunity to benefit directly from the vast resources and knowledge that Drosophila offers as a genetically amenable, rapidly growing and relatively inexpensive model system. This work has the potential to identify essential pathway(s) and processes involved in development of the structures that are defective in CDH.

果蝇核心的总体目标和摘要 100多年的研究已经建立了常见的果蝇--黑腹果蝇，作为主要的模型系统。随着翻译研究、系统生物学和基因组学的成熟，研究人员越来越多地转向更简单的模型系统，以深入了解他们感兴趣的特定基因中遗传损伤的分子机制和表型结果。到目前为止，人类中60%的疾病相关基因在果蝇中具有保守的对应物。此外，几乎所有与癌症、代谢性疾病和先天性出生缺陷有关的信号通路在果蝇中都是保守的。果蝇遗传学和RNAi核心是为了服务于这个项目而设计的，它使研究人员有机会直接从果蝇提供的大量资源和知识中受益，这些资源和知识是果蝇作为一种遗传服从、快速增长和相对便宜的模型系统提供的。这项工作有可能确定CDH中有缺陷的结构的发展所涉及的基本途径(S)和过程。