THE DROSOPHILA GENETICS AND RNAI CORE (THE FLY CORE)

Drosophila Core的总体目标和摘要 经过100多年的研究，普通果蝇（Drosophila melanogaster）已经成为首要的模型系统。随着转化研究、系统生物学和基因组学的成熟，研究人员越来越多地转向更简单的模型系统，以深入了解特定基因中遗传病变的分子机制和表型结果。迄今为止，人类60%的疾病相关基因在苍蝇中具有保守的对应物。此外，几乎所有与癌症、代谢性疾病和先天性出生缺陷有关的信号通路在果蝇中都是保守的。Drosophila Genetics and RNAi Core旨在为该计划项目服务，使研究人员有机会直接受益于果蝇作为一个遗传上适合的，快速增长的和相对便宜的模型系统提供的大量资源和知识。这项工作有可能确定参与CDH缺陷结构发育的重要途径和过程。

Drosophila Core's overall objectives and Abstract Over 100 years of research has established the common fruit fly, Drosophila melanogaster, as a premier model system. As translational research, systems biology and genomics come of age, researchers are increasingly turning to more simple model systems to gain insights into the molecular mechanisms and phenotypic outcomes of genetic lesions in their particular genes of interest. To date, 60% of disease related genes in humans have conserved counterparts in flies. Further, virtually all of the signaling pathways implicated in cancer, metabolic diseases, and congenital birth defects are conserved in flies. The Drosophila Genetics and RNAi Core, designed to serve this program project, allows researchers the opportunity to benefit directly from the vast resources and knowledge that Drosophila offers as a genetically amenable, rapidly growing and relatively inexpensive model system. This work has the potential to identify essential pathway(s) and processes involved in development of the structures that are defective in CDH.