Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions

中间丝：运动性、马达和细胞骨架相互作用

• 批准号: 8142483
• 负责人: Vladimir I Gelfand
• 金额: $ 27.45万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8142483
• 关键词: Actins; Affect; Affinity Chromatography; Behavior; Biochemical; Cell surface; Cells; Complex; Cytoplasm; DNA Sequence Rearrangement; Data; Dynein ATPase; Goals; Image; Individual; Intermediate Filaments; Kinesin; Maps; Mechanical Stress; Mechanics; Mediating; Microfilaments; Microtubule Depolymerization; Microtubule Polymerization; Microtubules; Motor; Movement; Myosin ATPase; Phosphorylation; Polymers; Protein Isoforms; Proteins; Publishing; RNA Splicing; Reagent; Regulation; Side; Signal Transduction; Slide; Small Interfering RNA; Stress; Techniques; Time; Vimentin; base; cell motility; crosslink; depolymerization; link protein; member; particle; research study; response; shear stress; spatial relationship

Our long-term objective is to understand the mechanisms of interaction between vimentin intermediate filaments (VIF) and the two other cytoskeletal components, microtubules (MTs) and microfilaments (MFs). Our hypothesis is that MT and MF, via motor proteins, guide the formation and the proper distribution of the VIF network. At the same time, the VIF network modulates MT and MF dynamics and behavior.

我们的长期目标是了解波形蛋白与血管内皮细胞之间的相互作用机制。 中间丝（VIF）和其他两种细胞骨架成分，微管（MT）和微丝（MF）。我们的假设是，MT和MF，通过马达蛋白，指导VIF网络的形成和正确的分布。同时，VIF网络调节MT和MF动力学和行为。