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Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions

Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions
中间丝：运动性、马达和细胞骨架相互作用
批准号：
8142483
负责人：
Vladimir I Gelfand
金额：
$27.45万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-06-15 至 2016-05-31
来源：
https://reporter.nih.gov/project-details/8142483
关键词：
ActinsAffectAffinity ChromatographyBehaviorBiochemicalCell surfaceCellsComplexCytoplasmDNA Sequence RearrangementDataDynein ATPaseGoalsImageIndividualIntermediate FilamentsKinesinMapsMechanical StressMechanicsMediatingMicrofilamentsMicrotubule DepolymerizationMicrotubule PolymerizationMicrotubulesMotorMovementMyosin ATPasePhosphorylationPolymersProtein IsoformsProteinsPublishingRNA SplicingReagentRegulationSideSignal TransductionSlideSmall Interfering RNAStressTechniquesTimeVimentinbasecell motilitycrosslinkdepolymerizationlink proteinmemberparticleresearch studyresponseshear stressspatial relationship

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中文摘要
翻译
我们的长期目标是了解波形蛋白之间的相互作用机制 中间丝(VIF)和另外两个细胞骨架成分，微管(MTS)和微丝(MFS)。我们的假设是MT和MF通过马达蛋白引导VIF网络的形成和适当的分布。同时，VIF网络调节MT和MF的动态和行为。
英文摘要
Our long-term objective is to understand the mechanisms of interaction between vimentin intermediate filaments (VIF) and the two other cytoskeletal components, microtubules (MTs) and microfilaments (MFs). Our hypothesis is that MT and MF, via motor proteins, guide the formation and the proper distribution of the VIF network. At the same time, the VIF network modulates MT and MF dynamics and behavior.
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Microtubule motors, cytoskeletal organization and cell polarity
Microtubule motors, cytoskeletal organization and cell polarity
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Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions
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