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Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions

Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions
中间丝：运动性、马达和细胞骨架相互作用
批准号：
8142483
负责人：
Vladimir I Gelfand
金额：
$27.45万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-06-15 至 2016-05-31
来源：
https://reporter.nih.gov/project-details/8142483
关键词：
ActinsAffectAffinity ChromatographyBehaviorBiochemicalCell surfaceCellsComplexCytoplasmDNA Sequence RearrangementDataDynein ATPaseGoalsImageIndividualIntermediate FilamentsKinesinMapsMechanical StressMechanicsMediatingMicrofilamentsMicrotubule DepolymerizationMicrotubule PolymerizationMicrotubulesMotorMovementMyosin ATPasePhosphorylationPolymersProtein IsoformsProteinsPublishingRNA SplicingReagentRegulationSideSignal TransductionSlideSmall Interfering RNAStressTechniquesTimeVimentinbasecell motilitycrosslinkdepolymerizationlink proteinmemberparticleresearch studyresponseshear stressspatial relationship

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中文摘要
翻译
我们的长期目标是了解波形蛋白之间相互作用的机制
英文摘要
Our long-term objective is to understand the mechanisms of interaction between vimentin intermediate filaments (VIF) and the two other cytoskeletal components, microtubules (MTs) and microfilaments (MFs). Our hypothesis is that MT and MF, via motor proteins, guide the formation and the proper distribution of the VIF network. At the same time, the VIF network modulates MT and MF dynamics and behavior.
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Intermediate Filaments: Motility, Motors and Cytoskeletal Interactions
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