Investigation of novel mechanisms for the regulation of sperm-oocyte interactions

研究调节精子-卵母细胞相互作用的新机制

• 批准号: FT140101368
• 负责人: Prof Brett Nixon
• 金额: $ 60.08万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140101368
• 关键词: Investigation; novel; mechanisms; regulation; sperm

Through work with national and international collaborators, this project aims to provide unprecedented insights into how spermatozoa recognise and bind to an oocyte. The approach is based on strong preliminary data indicating that molecular chaperones play a key role in the functional remodelling of the spermatozoon by promoting the assembly of multimeric oocyte receptor complexes. Through the use of state-of-the-art cell biology and proteomic technologies, the project aims to investigate how molecular chaperones orchestrate these changes and in doing so, improve understanding of the fertilisation cascade and open up new contraceptive strategies.

通过与国家和国际合作者的合作，该项目旨在提供关于精子如何识别和结合卵母细胞的前所未有的见解。该方法是基于强有力的初步数据表明，分子伴侣通过促进多聚体卵母细胞受体复合物的组装在精子的功能重塑中发挥关键作用。通过使用最先进的细胞生物学和蛋白质组学技术，该项目旨在研究分子伴侣如何协调这些变化，并在此过程中提高对受精级联的理解，并开辟新的避孕策略。