Investigation of the mechanisms underpinning HSPA2 dysfunction in the spermatozoa of infertile patients

不孕患者精子 HSPA2 功能障碍的机制研究

• 批准号: nhmrc : 1101953
• 负责人: Prof Brett Nixon
• 金额: $ 33万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-mechanisms-underpinning-infertile-patients/662577
• 关键词: Investigation; mechanisms; underpinning; HSPA2; dysfunction

Male infertility is an extremely common condition, that is frequently associated with the production of sperm that have lost their ability to recognize the egg. We have shown that this defect is frequently associated with a deficiency in a specific protein (HSPA2). By determining the mechanisms underpinning the loss of HSPA2, this project will provide powerful insights into the causes of male infertility, with practical implications for prevention, diagnosis and treatment of this condition.

男性不育是一种非常常见的疾病，通常与精子的产生有关，这些精子失去了识别卵子的能力。我们已经表明，这种缺陷通常与特定蛋白（HSPA2）的缺乏有关。通过确定HSPA2丢失的机制，该项目将为男性不育的原因提供强有力的见解，对预防，诊断和治疗这种疾病具有实际意义。