Characterization of the molecular basis of human sperm-oocyte interaction

人类精子-卵母细胞相互作用的分子基础的表征

• 批准号: nhmrc : 569235
• 负责人: Prof Brett Nixon
• 金额: $ 32.87万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-molecular-basis-oocyte-interaction/82451
• 关键词: Characterization; molecular; basis; human; sperm

In this proposal, we shall exploit our expertise in gamete biology and innovative proteomic technologies to elucidate the molecular mechanisms that underpin human sperm-oocyte interaction. This exquisitely cell- and species-specific event constitutes one of the most strategically important cellular interactions. Our research will provide the foundation for diagnosis and treatment of male infertility and identify a range of targets for the development of novel contraceptive technology.

在这个提案中，我们将利用我们在配子生物学和创新蛋白质组技术方面的专业知识来阐明支撑人类精子-卵母细胞相互作用的分子机制。这一精致的细胞和物种特有的事件构成了最具战略意义的细胞相互作用之一。我们的研究将为男性不育的诊断和治疗提供基础，并为开发新的避孕技术确定一系列靶点。