The role of dynamin in spermatogenesis, sperm maturation and sperm-oocyte interactions

动力在精子发生、精子成熟和精子-卵母细胞相互作用中的作用

• 批准号: nhmrc : 1103176
• 负责人: Prof Brett Nixon
• 金额: $ 37.84万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dynamin-spermatogenesis-oocyte-interactions/662660
• 关键词: role; dynamin; spermatogenesis; sperm; maturation

Male infertility is an extremely common condition affecting 1 in 20 Australian men. One of the major reasons for this pathology is that the spermatozoa have lost their ability to interact with the egg and penetrate its outer vestments. In this project we shall investigate the role of dynamin in the regulation of these events. This research will provide new and powerful insights into the causes of male infertility, with practical implications for diagnosis and treatment of this condition.

男性不育症是一种非常常见的疾病，每20名澳大利亚男性中就有1人患有这种疾病。这种病理学的主要原因之一是精子失去了与卵子相互作用并穿透其外膜的能力。在这个项目中，我们将研究发动蛋白在这些事件的调节中的作用。这项研究将为男性不育的原因提供新的和强有力的见解，对这种疾病的诊断和治疗具有实际意义。