CLINICAL TRIAL: FAMILY THERAPY AND FLUOXETINE IN THE TREATMENT OF ADOLESCENT ANO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在一项充分有效的随机对照试验中，比较了行为家庭疗法(BFT)和系统家庭疗法(SFT)这两种理论上和程序上不同的治疗方法的相对短期和长期疗效，以及氟西汀与安慰剂对青少年神经性厌食症(AN)的相加作用。我们期望BFT在维持门诊患者的正常体重和营养方面优于SFT。然而，许多人仍会有症状。我们预计，在两组家庭治疗(FT)中，氟西汀在减少焦虑、强迫症和进食障碍(ED)特定症状方面都优于安慰剂。最后，由于营养正常化可能对氟西汀的反应至关重要，我们预计BFT+氟西汀组的总体反应和结果最好。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Compare the relative short and long term effectiveness of behavioral family therapy (BFT) and systems family therapy (SFT), two theoretically and procedurally distinct treatments, and the additive effects of fluoxetine compared to placebo for adolescent anorexia nervosa (AN) in an adequately powered randomized controlled trial. We expect BFT to be superior to SFT in maintaining normal weight and nutrition as outpatients. However, many individuals will remain symptomatic. We expect fluoxetine to be superior to placebo in terms of reducing anxiety, obsessionality, and eating disorder (ED) specific symptoms in both family therapy (FT) groups. Finally, because normalized nutrition may be critical for fluoxetine response, we would expect the BFT + fluoxetine group to have the best overall response and outcome.