TRAIT RELATED DISTURBANCE IN ANOREXIA AND BULIMIA NERVOSA

神经性厌食症是一种病因不明的疾病， 身体形象紊乱，食物摄入量明显减少， 对苗条的执着追求，刻板的刻板印象和完美主义， 以及频繁的情绪和神经内分泌紊乱。 减肥后 恢复，这些干扰的严重程度降低，但它们可能 而不是正常化。 神经递质的相对贡献 异常的持续病理生理学尚不清楚。 有 有理由认为，大脑5-羟色胺通路的活性增加可能 做贡献。 我们初步的心理学数据显示焦虑和强迫症 行为存在于神经性厌食症的所有阶段，但可能更多 在体重恢复后明显。 我们会研究体重不足和身材矮小- 长期体重恢复正常。 我们假设m-CPP给药 不会使体重过轻的肥胖者产生焦虑和强迫性思维 并且这些症状在体重恢复阶段后会更严重。

Anorexia nervosa, a disorder of unknown etiology, is characterized by a disturbed body image, the marked diminution of food intake in the obsessive pursuit of thinness, a stereotypic rigidity and perfectionsism, and frequent mood and neuroendocrine disturbances. After weight restoration, there is reduced severity of these disturbances but they may not normalize. The relative contribution of neurotransmitter(s) abnormalities to the persistent pathophysiology is unclear. There are reasons to think that increased activity of brain serotonin pathways may be contributory. Our preliminary psychological data suggests that anxious and obsessional behavior is present at all stages of anorexia nervosa, but may be more pronounced after weight recovery. We will study underweight and short- term weight restored anorexics. We hypothesize that m-CPP administraiton will not produce anxiety and obsessive thinking in underweight anorexics and that such symptoms will be worse after stages of weight restoration.