NEUROBIOLOGY OF ANOREXIA AND BULIMIA NERVOSA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目标1：我们预测，相对于对照组女性（CW），前额叶（AI）和眶额叶皮层（OFC）对蔗糖（相对于离子水）的反应将在REC AN中减少，而在REC BN中在空腹和进食状态下被夸大，表明异常的稳态张力。 目标2：我们预测，相对于CW，AI/OFC对糖的反应相对于离子水的变化将在REC AN中减少，而在REC BN中被夸大，当进食状态与禁食状态相比时，这表明对饥饿的稳态反应改变。 目标3（探索性）：我们将探讨饥饿是否会增加BN的焦虑和减少AN的焦虑，以及抗焦虑的变化是否与AI激活相关。我们将探讨RECAN和BN是否具有独立于摄食行为调节的奖励和认知功能障碍。我们还将确定认知和行为数据是否与神经功能发现相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1: We predict that, relative to control women (CW), anterior insula (AI) and orbital frontal cortex (OFC) response to sucrose (relative to ionic water) will be diminished in REC AN and exaggerated in REC BN in both the fasting and fed states, indicating an aberrant homeostatic tone. AIM 2: We predict that, relative to CW, the change in AI/OFC response to sugar relative to ionic water will be diminished in REC AN and exaggerated in REC BN, when the fed state is compared to the fasting state, suggesting an altered homeostatic response to hunger. AIM 3 (exploratory): We will explore whether hunger increases anxiety in BN and decreases anxiety in AN, and whether anxiolytic changes are associated with AI activation. We will explore whether REC AN and BN have disturbances of reward and cognitive function that are independent of modulation of feeding behaviors. We will also determine whether cognition and behavioral data correlate with neuro-functional findings.