NEUROBIOLOGY OF ANOREXIA AND BULIMIA NERVOSA

厌食症和神经性贪食症的神经生物学

• 批准号: 7951003
• 负责人: WALTER KAYE
• 金额: $ 0.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951003
• 关键词: Anorexia; Anterior; Anti-Anxiety Agents; Anxiety; Behavioral; Bulimia; Clinical Research; Cognition; Computer Retrieval of Information on Scientific Projects Database; Data; Fasting; Feeding behaviors; Funding; Grant; Hunger; Institution; Insula of Reil; Neurobiology; Relative (related person); Research; Research Personnel; Resources; Rewards; Source; Sucrose; United States National Institutes of Health; Water; Woman; cognitive function; feeding; frontal lobe; increased appetite; response; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1: We predict that, relative to control women (CW), anterior insula (AI) and orbital frontal cortex (OFC) response to sucrose (relative to ionic water) will be diminished in REC AN and exaggerated in REC BN in both the fasting and fed states, indicating an aberrant homeostatic tone. AIM 2: We predict that, relative to CW, the change in AI/OFC response to sugar relative to ionic water will be diminished in REC AN and exaggerated in REC BN, when the fed state is compared to the fasting state, suggesting an altered homeostatic response to hunger. AIM 3 (exploratory): We will explore whether hunger increases anxiety in BN and decreases anxiety in AN, and whether anxiolytic changes are associated with AI activation. We will explore whether REC AN and BN have disturbances of reward and cognitive function that are independent of modulation of feeding behaviors. We will also determine whether cognition and behavioral data correlate with neuro-functional findings.

这个子项目是众多研究子项目之一