TRAIT RELATED DISTURBANCE IN ANOREXIA AND BULIMIA NERVOSA

神经性厌食症是一种病因不明的疾病，其特征是身体意象紊乱，在强迫性追求苗条的过程中食物摄入明显减少，刻板的刻板僵化和完美主义，以及频繁的情绪和神经内分泌紊乱。 体重恢复后，这些紊乱的严重程度降低，但可能无法正常化。神经递质异常对持续性病理生理学的相对贡献尚不清楚。 有理由认为，大脑5-羟色胺通路的活性增加可能是促成因素。我们的初步心理学数据表明，焦虑和强迫行为存在于神经性厌食症的各个阶段，但在体重恢复后可能更加明显。 我们将研究体重不足和短期体重恢复的减肥药。 我们假设，m-CPP管理不会产生焦虑和强迫性思维在体重不足的肥胖症患者，这些症状将在体重恢复阶段后更糟。

Anorexia nervosa, a disorder of unknown etiology, is characterized by a disturbed body image, the marked diminution of food intake in the obsessive pursuit of thinness, a stereotypic rigidity and perfectionsism, and frequent mood and neuroendocrine disturbances. After weight restoration, there is reduced severity of these disturbances but they may not normalize. The relative contribution of neurotransmitter(s) abnormalities to the persistent pathophysiology is unclear. There are reasons to think that increased activity of brain serotonin pathways may be contributory. Our preliminary psychological data suggests that anxious and obsessional behavior is present at all stages of anorexia nervosa, but may be more pronounced after weight recovery. We will study underweight and short-term weight restored anorexics. We hypothesize that m-CPP administration will not produce anxiety and obsessive thinking in underweight anorexics and that such symptoms will be worse after stages of weight restoration.