ESTROGEN DEFICIENCY AND CARDIOVASCULAR DISEASE IN PREMENOPAUSAL WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 与年龄匹配的男性相比，患有心脏病的年轻绝经前女性与冠状动脉事件相关的死亡率是男性的两倍。动物实验表明，生殖猴子在压力下会出现中枢性(下丘脑)闭经，导致雌激素缺乏。这些猴子随后被发现患上了过早的冠状动脉疾病。我们想要研究绝经前妇女的这种关系，以进一步评估雌激素缺乏与冠状动脉疾病之间的可能联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Young, premenopausal women with heart disease have twice the rate of death related to coronary events when compared to age matched men. Animal experiments have shown that reproductive monkeys when exposed to stress develop central (hypothalamic) amenorrhea leading to estrogen deficiency. These monkeys subsequently were noted to develop premature coronary artery disease. We want to study this relationship in premenopausal women to further evaluate a possible link between estrogen deficiency and coronary artery disease.