MAE-WEST SCORE Leadership Administrative Core
MAE-WEST SCORE 领导力行政核心
基本信息
- 批准号:10198756
- 负责人:
- 金额:$ 23.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdministrative CoordinationAdvisory CommitteesAdvocateAgeAgingAlzheimer&aposs disease related dementiaAnnual ReportsAreaBasic ScienceBioinformaticsBiologicalBiological AgingBiostatistics CoreBlood VesselsBrainBudgetsCardiologyCenters of Research ExcellenceChronicChronic Kidney FailureChronologyClinical ResearchClinical SciencesCollaborationsCommunicationCommunitiesData SetDatabasesDiseaseDisease OutcomeEFRACEducational CurriculumEducational workshopEicosanoidsElderlyEnsureEpidemiologistEvaluationFailureFeedbackFemaleFinancial SupportFoundationsFunctional disorderFundingGenerationsGeriatricsGoalsGonadal Steroid HormonesGrantHeart failureHumanInflammationInflammatoryInfrastructureInstitutionInterdisciplinary StudyInvestigationLeadLeadershipLettersLife Cycle StagesLongevityMediator of activation proteinMentorsMicrovascular DysfunctionMissionMonitorMorbidity - disease rateNatureNephrologyOrganParticipantPilot ProjectsPopulation SciencesPreparationProductivityProgress ReportsPublic HealthPublicationsRenal functionReportingRequest for ApplicationsResearchResearch PersonnelResearch Project GrantsResource AllocationResource SharingResourcesScientific Advances and AccomplishmentsScientistSeedsServicesSex DifferencesSpecialized CenterStructureTrainingTraining ActivityTranslatingTranslationsVariantWomanWomen&aposs HealthWorkage effectage relatedbasecareercareer developmentclinical developmentdata disseminationdata sharingeffective interventionexperiencefrailtyheart functionimprovedinter-institutionalmalemeetingsmenmicrovascular agingnext generationoperationorganizational structurepreservationprogramspublic repositoryresponsescientific organizationsexsexual dimorphismstressortranslational scientist
项目摘要
Project Abstract – MAE-WEST SCORE LAC
Over the course of life, chronic stressors contribute to multi-organ aging and dysfunction and, ultimately, the
development of clinical disease. Sex remains a critical determinant of the nature and pace of aging and ultimately
longevity. Among mammalian species, it is even more clear that females fundamentally age differently from
males. With advancing chronologic age in humans, differences in biological aging between women and men
become even more pronounced, culminating in the female predominance for a number of important morbid
disease conditions, including notably Alzheimer’s disease and related dementias (ADRD), heart failure with
preserved ejection fraction (HFpEF), progressive chronic kidney disease (CKD), and in turn systemic frailty.
Mechanisms underlying the female predominance for these major morbidities remains unknown and are not
explained by variations in sex hormones or survival bias. Our preliminary work supports a central hypothesis that
sexual dimorphism in inflammatory eicosanoid mediators contribute to sex differences in microvascular
dysfunction and, in turn, to sex differences in age-related multi-organ disease, including for ADRD, HFpEF and
CKD. Elucidating a common pathophysiologic basis for the female predominance of ADRD, HFpEF, and CKD
holds the key to effective interventions for reducing the excess burden of age-related disease in women.
Motivated our findings and the critical need to understand the determinants and drivers of sex differences in
major age-related disease outcomes, we propose to establish the Microvascular Aging and Eicosanoids –
Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”)
Specialized Center of Research Excellence (SCORE) on Sex Differences, in response to NIH RFA-OD-19-013.
Our goal is to form a robust and sustainable structure of academic activities centered on systematically
interrogating sex differences in the relationship among eicosanoids, microvascular dysfunction, and age-related
end-organ disease, with an initial focus on the microvascular aging effects on brain, heart, and kidney function.
This goal will be achieved by an outstanding collaborative team of clinician-scientists (with expertise in geriatrics,
cardiology, and nephrology), epidemiologists, basic and translational scientists, analytical chemists,
biostatisticians, and bioinformaticians. Leveraging our collective experience, resources, and infrastructure, we
will advance the scientific enterprise through 3 foundational projects aligned and complementary yet
independent. To realize the full potential of this ambitious scientific and educational agenda, we have established
a Leadership Administrative Core, for overseeing operations, fiduciary responsibility, and enabling efficiency. In
establishing the MAE-WEST SCORE, we will extend from existing collaborations and formalize an organization
of scientific and mentoring leadership that is intended to prioritize inter-institutional as well as inter-disciplinary
integration of all activities, including routine sharing of research findings across the major areas of population,
clinical, and basic science.
项目摘要- MAE-WEST SCORE LAC
在生命过程中,慢性应激源导致多器官衰老和功能障碍,最终,
临床疾病的发展。性仍然是衰老的性质和速度的关键决定因素,
中心blog在哺乳动物物种中,更明显的是,雌性的衰老与雌性的衰老根本不同。
男性。随着人类生理年龄的增长,女性和男性之间的生物衰老差异
变得更加明显,最终在女性占主导地位的一些重要的病态
疾病状况,尤其包括阿尔茨海默病和相关痴呆(ADRD)、心力衰竭伴
射血分数保留(HFpEF)、进行性慢性肾病(CKD),进而全身虚弱。
这些主要发病率女性占优势的机制仍然未知,
这可以用性激素的变化或生存偏差来解释。我们的初步工作支持一个中心假设,
炎症性类二十烷酸介质的性别二态性导致微血管中的性别差异
功能障碍,反过来,与年龄相关的多器官疾病的性别差异,包括ADRD,HFpEF和
CKD。阐明ADRD、HFpEF和CKD女性优势的共同病理生理学基础
是采取有效干预措施减少妇女年龄相关疾病过度负担的关键。
激发了我们的研究结果,并迫切需要了解性别差异的决定因素和驱动因素,
主要的年龄相关疾病的结果,我们建议建立微血管老化和类花生酸-
女性系统老化韧性评估(MAE-WEST)(“你永远不会太老,变得年轻!”)
性别差异卓越研究专业中心(SCORE),响应NIH RFA-OD-19-013。
我们的目标是形成一个强大的和可持续的学术活动结构,
询问类二十烷酸、微血管功能障碍和年龄相关性之间关系的性别差异
终末器官疾病,最初的重点是微血管老化对大脑,心脏和肾脏功能的影响。
这一目标将由一个杰出的临床医生-科学家(具有老年医学专业知识,
心脏病学和肾脏病学),流行病学家,基础和转化科学家,分析化学家,
生物统计学家和生物信息学家。利用我们的集体经验、资源和基础设施,
将通过3个基础项目来推进科学事业,这些项目是一致和互补的,
独立的为了充分发挥这一雄心勃勃的科学和教育议程的潜力,我们建立了
a领导管理核心,用于监督运营、受托责任和提高效率。在
建立MAE-WEST SCORE,我们将从现有的合作中扩展,并正式建立一个组织
科学和指导领导,旨在优先考虑机构间和学科间
整合所有活动,包括定期分享人口各主要领域的研究成果,
临床和基础科学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cathleen Noel Bairey Merz其他文献
Cathleen Noel Bairey Merz的其他文献
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{{ truncateString('Cathleen Noel Bairey Merz', 18)}}的其他基金
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
微血管老化和类二十烷酸 - 女性全身老化韧性评估 (MAE-WEST)(“你永远不会太老,变得更年轻!”)卓越研究专业中心 (SCORE)
- 批准号:
10198755 - 财政年份:2020
- 资助金额:
$ 23.07万 - 项目类别:
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
微血管老化和类二十烷酸 - 女性全身老化韧性评估 (MAE-WEST)(“你永远不会太老,变得更年轻!”)卓越研究专业中心 (SCORE)
- 批准号:
10450755 - 财政年份:2020
- 资助金额:
$ 23.07万 - 项目类别:
MAE-WEST SCORE Leadership Administrative Core
MAE-WEST SCORE 领导力行政核心
- 批准号:
10450756 - 财政年份:2020
- 资助金额:
$ 23.07万 - 项目类别:
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
微血管老化和类二十烷酸 - 女性全身老化韧性评估 (MAE-WEST)(“你永远不会太老,变得更年轻!”)卓越研究专业中心 (SCORE)
- 批准号:
10817498 - 财政年份:2020
- 资助金额:
$ 23.07万 - 项目类别:
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
女性缺血综合征评估 (WISE) - 冠状动脉微血管功能障碍导致射血分数保留 (HFpEF) 的先兆心力衰竭的机制
- 批准号:
9922714 - 财政年份:2019
- 资助金额:
$ 23.07万 - 项目类别:
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
女性缺血综合征评估 (WISE) - 冠状动脉微血管功能障碍导致射血分数保留 (HFpEF) 的先兆心力衰竭的机制
- 批准号:
10576287 - 财政年份:2019
- 资助金额:
$ 23.07万 - 项目类别:
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