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MAE-WEST SCORE Leadership Administrative Core

MAE-WEST SCORE 领导力行政核心

基本信息

批准号：
10450756
负责人：
Cathleen Noel Bairey Merz
金额：
$ 22.81万
依托单位：
CEDARS-SINAI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10450756
关键词：
Address Administrative Coordination Advisory Committees Advocate Age Aging Alzheimer&apos s disease related dementia Annual Reports Area Basic Science Bioinformatics Biological Biological Aging Biostatistics Core Blood Vessels Brain Budgets Cardiology Centers of Research Excellence Chronic Chronic Kidney Failure Chronology Clinical Research Clinical Sciences Collaborations Communication Communities Data Set Databases Disease Disease Outcome EFRAC Educational Curriculum Educational workshop Eicosanoids Elderly Ensure Epidemiologist Evaluation Failure Feedback Female Financial Support Foundations Functional disorder Funding Generations Geriatrics Goals Gonadal Steroid Hormones Grant Heart failure Human Inflammation Inflammatory Infrastructure Institution Interdisciplinary Study Investigation Lead Leadership Letters Life Cycle Stages Longevity Mediator of activation protein Mentors Microvascular Dysfunction Mission Monitor Morbidity - disease rate Nature Nephrology Organ Participant Pilot Projects Population Sciences Preparation Productivity Progress Reports Public Health Publications Renal function Reporting Request for Applications Research Research Personnel Research Project Grants Resource Allocation Resource Sharing Resources Scientific Advances and Accomplishments Scientist Seeds Services Sex Differences Specialized Center Structure Training Training Activity Translating Translations Variant Woman Women&apos s Health Work age effect age related base career career development clinical development data dissemination data sharing effective intervention experience frailty heart function improved inter-institutional male meetings men microvascular aging next generation operation organizational structure preservation programs public repository response scientific organization sex sexual dimorphism stressor translational scientist

项目摘要

Project Abstract – MAE-WEST SCORE LAC Over the course of life, chronic stressors contribute to multi-organ aging and dysfunction and, ultimately, the development of clinical disease. Sex remains a critical determinant of the nature and pace of aging and ultimately longevity. Among mammalian species, it is even more clear that females fundamentally age differently from males. With advancing chronologic age in humans, differences in biological aging between women and men become even more pronounced, culminating in the female predominance for a number of important morbid disease conditions, including notably Alzheimer’s disease and related dementias (ADRD), heart failure with preserved ejection fraction (HFpEF), progressive chronic kidney disease (CKD), and in turn systemic frailty. Mechanisms underlying the female predominance for these major morbidities remains unknown and are not explained by variations in sex hormones or survival bias. Our preliminary work supports a central hypothesis that sexual dimorphism in inflammatory eicosanoid mediators contribute to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease, including for ADRD, HFpEF and CKD. Elucidating a common pathophysiologic basis for the female predominance of ADRD, HFpEF, and CKD holds the key to effective interventions for reducing the excess burden of age-related disease in women. Motivated our findings and the critical need to understand the determinants and drivers of sex differences in major age-related disease outcomes, we propose to establish the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences, in response to NIH RFA-OD-19-013. Our goal is to form a robust and sustainable structure of academic activities centered on systematically interrogating sex differences in the relationship among eicosanoids, microvascular dysfunction, and age-related end-organ disease, with an initial focus on the microvascular aging effects on brain, heart, and kidney function. This goal will be achieved by an outstanding collaborative team of clinician-scientists (with expertise in geriatrics, cardiology, and nephrology), epidemiologists, basic and translational scientists, analytical chemists, biostatisticians, and bioinformaticians. Leveraging our collective experience, resources, and infrastructure, we will advance the scientific enterprise through 3 foundational projects aligned and complementary yet independent. To realize the full potential of this ambitious scientific and educational agenda, we have established a Leadership Administrative Core, for overseeing operations, fiduciary responsibility, and enabling efficiency. In establishing the MAE-WEST SCORE, we will extend from existing collaborations and formalize an organization of scientific and mentoring leadership that is intended to prioritize inter-institutional as well as inter-disciplinary integration of all activities, including routine sharing of research findings across the major areas of population, clinical, and basic science.

项目摘要- MAE-WEST SCORE LAC