MAE-WEST SCORE Project 2 Clinical

MAE-WEST SCORE 项目 2 临床

基本信息

  • 批准号:
    10198761
  • 负责人:
  • 金额:
    $ 73.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Project Abstract – MAE-WEST SCORE Project 2 Over the course of life, chronic stressors contribute to multi-organ aging and dysfunction and, ultimately, the development of clinical disease. Sex remains a critical determinant of the nature and pace of aging and ultimately longevity. Among mammalian species, it is even more clear that females fundamentally age differently from males. With advancing chronologic age in humans, differences in biological aging between women and men become even more pronounced, culminating in the female predominance for a number of important morbid disease conditions, including notably Alzheimer’s disease and related dementias (ADRD), heart failure with preserved ejection fraction (HFpEF), progressive chronic kidney disease (CKD), and in turn systemic frailty. Mechanisms underlying the female predominance for these major morbidities remains unknown and are not explained by variations in sex hormones or survival bias. Our preliminary work supports that sexual dimorphism in inflammatory eicosanoid mediators contribute to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease, including for ADRD, HFpEF and CKD. Elucidating a common pathophysiologic basis for the female predominance of ADRD, HFpEF, and CKD holds the key to effective interventions for reducing the excess burden of age-related disease in women. Motivated our findings and the critical need to understand the determinants and drivers of sex differences in major age-related disease outcomes, we propose to establish the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences, in response to NIH RFA-OD-19-013. Our goal is to form a robust and sustainable structure of academic activities centered on systematically interrogating sex differences in the relationship among eicosanoids, microvascular dysfunction, and age-related end-organ disease, with an initial focus on the microvascular aging effects on brain, heart, and kidney function. This goal will be achieved by an outstanding collaborative team of clinician-scientists (with expertise in geriatrics, cardiology, and nephrology), epidemiologists, basic and translational scientists, analytical chemists, biostatisticians, and bioinformaticians. Leveraging our collective experience, resources, and infrastructure, we will advance the scientific enterprise through 3 foundational projects aligned and complementary yet independent. Project 2 will determine the sex- specific association of eicosanoids with microvascular physiology in women and men and the role of FDA approved agents in modulation of total microvascular disease burden. In a sample of women and men with deep clinical phenotyping, this clinical science project will examine sex differences in the relations of eicosanoids with the co-occurrence of microvascular aging traits across major organ systems (brain, heart, kidney, systemic frailty) and evaluate the effects of intensive medical treatment with high-intensity statin plus ACEi or ARB therapy on both eicosanoid profiles and total microvascular disease burden.
项目摘要- MAE-WEST SCORE项目2

项目成果

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Cathleen Noel Bairey Merz其他文献

Cathleen Noel Bairey Merz的其他文献

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{{ truncateString('Cathleen Noel Bairey Merz', 18)}}的其他基金

MAE-WEST SCORE Project 2 Clinical
MAE-WEST SCORE 项目 2 临床
  • 批准号:
    10450762
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
微血管老化和类二十烷酸 - 女性全身老化韧性评估 (MAE-WEST)(“你永远不会太老,变得更年轻!”)卓越研究专业中心 (SCORE)
  • 批准号:
    10198755
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
MAE-WEST SCORE Career Enhance Core
MAE-WEST SCORE 职业提升核心
  • 批准号:
    10450757
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
微血管老化和类二十烷酸 - 女性全身老化韧性评估 (MAE-WEST)(“你永远不会太老,变得更年轻!”)卓越研究专业中心 (SCORE)
  • 批准号:
    10450755
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
MAE-WEST SCORE Leadership Administrative Core
MAE-WEST SCORE 领导力行政核心
  • 批准号:
    10450756
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
MAE-WEST SCORE Career Enhance Core
MAE-WEST SCORE 职业提升核心
  • 批准号:
    10198757
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
MAE-WEST SCORE Leadership Administrative Core
MAE-WEST SCORE 领导力行政核心
  • 批准号:
    10198756
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
微血管老化和类二十烷酸 - 女性全身老化韧性评估 (MAE-WEST)(“你永远不会太老,变得更年轻!”)卓越研究专业中心 (SCORE)
  • 批准号:
    10817498
  • 财政年份:
    2020
  • 资助金额:
    $ 73.29万
  • 项目类别:
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
女性缺血综合征评估 (WISE) - 冠状动脉微血管功能障碍导致射血分数保留 (HFpEF) 的先兆心力衰竭的机制
  • 批准号:
    9922714
  • 财政年份:
    2019
  • 资助金额:
    $ 73.29万
  • 项目类别:
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
女性缺血综合征评估 (WISE) - 冠状动脉微血管功能障碍导致射血分数保留 (HFpEF) 的先兆心力衰竭的机制
  • 批准号:
    10576287
  • 财政年份:
    2019
  • 资助金额:
    $ 73.29万
  • 项目类别:

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