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MAE-WEST SCORE Career Enhance Core

MAE-WEST SCORE 职业提升核心

基本信息

批准号：
10198757
负责人：
Cathleen Noel Bairey Merz
金额：
$ 14.29万
依托单位：
CEDARS-SINAI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10198757
关键词：
Address Advocate Age Aging Alzheimer&apos s disease related dementia Analytical Chemistry Area Basic Science Bioinformatics Biological Biological Aging Biometry Blood Vessels Brain California Cardiology Centers of Research Excellence Chemistry Chronic Chronic Disease Chronic Kidney Failure Chronology Clinical Clinical Research Clinical Trials Collaborations Communities Data Analytics Dementia Development Disease Disease Outcome EFRAC Education Eicosanoids Elderly Environment Epidemiologist Epidemiology Evaluation Faculty Failure Female Foundations Functional disorder Funding Geriatrics Gerontology Goals Gonadal Steroid Hormones Grant Heart Heart failure Human Inflammation Inflammatory Infrastructure Lead Life Cycle Stages Longevity Measurement Mediator of activation protein Medical Medical center Mentors Methodology Microvascular Dysfunction Mission Molecular Profiling Morbidity - disease rate Nature Nephrology Neurology Ophthalmology Organ Physiology Pilot Projects Productivity Public Health Renal function Request for Applications Research Research Activity Research Methodology Research Personnel Research Training Resources Scientific Advances and Accomplishments Scientist Seeds Sex Differences Specialized Center Structure Techniques Testing Training Training Activity Translating Translational Research Translations United States National Institutes of Health Universities Variant Woman Women&apos s Health Work age effect age related career career development clinical development effective intervention experience frailty hands on research health difference heart function implementation intervention improved infrastructure development innovation interdisciplinary approach men microvascular aging multidisciplinary neurocognitive test next generation population health preservation programs response sex sex disparity sexual dimorphism stressor translational scientist

项目摘要

Project Abstract – MAE-WEST SCORE CEC Over the course of life, chronic stressors contribute to multi-organ aging and dysfunction and, ultimately, the development of clinical disease. Sex remains a critical determinant of the nature and pace of aging and ultimately longevity. With advancing chronologic age in humans, differences in biological aging between women and men become even more pronounced, culminating in the female predominance for a number of important morbid disease conditions, including notably Alzheimer’s disease and related dementias (ADRD), heart failure with preserved ejection fraction (HFpEF), progressive chronic kidney disease (CKD), and in turn systemic frailty. Mechanisms underlying the female predominance for these major morbidities remains unknown and are not explained by variations in sex hormones or survival bias. Our preliminary work supports a central hypothesis that sexual dimorphism in inflammatory eicosanoid mediators contribute to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease, including for ADRD, HFpEF and CKD. Elucidating a common pathophysiologic basis for the female predominance of ADRD, HFpEF, and CKD holds the key to effective interventions for reducing the excess burden of age-related disease in women. Motivated our findings and the critical need to understand the determinants and drivers of sex differences in major age-related disease outcomes, we propose to establish the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences, in response to NIH RFA-OD-19-013. Our goal is to form a robust and sustainable structure of academic activities centered on systematically interrogating sex differences in the relationship among eicosanoids, microvascular dysfunction, and age-related end-organ disease, with an initial focus on the microvascular aging effects on brain, heart, and kidney function. This goal will be achieved by an outstanding collaborative team of clinician-scientists (with expertise in geriatrics, cardiology, and nephrology), epidemiologists, basic and translational scientists, analytical chemists, biostatisticians, and bioinformaticians. Leveraging our collective experience, resources, and infrastructure, we will advance the scientific enterprise through 3 foundational projects aligned and complementary yet independent. To promote and enhance the development of the next generation of early career investigators who are committed to studying sex differences in biomedicine, our MAE-WEST SCORE program will provide a robust, multi-disciplinary Career Enhancement Core. Methodological expertise areas include: epidemiology, clinical trials, basic science, analytical chemistry, biostatistics and bioinformatics, neurocognitive testing, integrated physiology, and global functional assessments. Content and clinical areas of expertise that will maximize the potential for translation of research findings to practice include: geriatrics and gerontology, neurology and neuro- ophthalmology, cardiology, nephrology, and women’s health.

项目摘要- MAE-WEST SCORE CEC