CARDIOVASCULAR DISEASE AND DIABETIC NEPHROPATHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 少数民族中2型糖尿病的患病率明显更高，这些人更有可能从他们的2型糖尿病中获得并发症，包括肾脏疾病。患有肾脏疾病的人更有可能患有心脏病；患有2型糖尿病和肾脏疾病的墨西哥裔美国人的风险概况以及疾病负担从未定义过。 这项研究是对患有糖尿病肾病的墨西哥裔美国人和非西班牙裔白人进行的前瞻性、观察性队列研究。这项研究的目的是确定一组患有糖尿病肾病的墨西哥裔美国人的基线动脉粥样硬化负荷(通过冠状动脉钙化评估)、动脉粥样硬化负荷的进展率以及总死亡率和心血管死亡率，并将其与一组患有糖尿病肾病的非西班牙裔白人进行比较。此外，还将研究动脉粥样硬化的几个危险因素对解释冠状动脉钙化负担的种族差异的贡献。两个新出现的因素(血浆同型半胱氨酸和血清瘦素水平)以及几个社会经济变量将被研究，以确定它们对冠状动脉钙化负担的种族差异的贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of type 2 diabetes is significantly higher in ethnic minorities and these individuals are morel likely to get complications from their type 2 diabetes, including kidney disease. Individuals with kidney disease are more likely to have heart disease; the risk profile as well as the disease burden in Mexican Americans with type 2 diabetes mellitus and kidney disease has never been defined. The study is a prospective, observational, cohort study of Mexican Americans and Non Hispanic Whites with diabetic nephropathy. The purpose of this study is to define the baseline atherosclerotic burden ( as assessed by coronary artery calcification) , the rate of progression of atherosclerotic burden and the total as well as cardiovascular mortality in a cohort of Mexican Americans with diabetic nephropathy and compare it to a cohort of non-Hispanic whites with diabetic nephropathy. Furthermore, the contribution of several risk factors for atherosclerosis to explain the ethnic differences in coronary artery calcification burden will be studied. Two emerging factors (plasma homocysteine and serum leptin levels) as well as several socio-economic variables will be studied to determine their contribution to the ethnic differences in coronary artery calcification burden.