CARDIOVASCULAR DISEASE AND DIABETIC NEPHROPATHY

心血管疾病和糖尿病肾病

• 批准号: 8174478
• 负责人: RAJNISH MEHROTRA
• 金额: $ 31.79万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174478
• 关键词: Atherosclerosis; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Diabetic Nephropathy; Funding; Grant; Homocysteine; Homocystine; Individual; Institution; Kidney Diseases; Leptin; Mexican Americans; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Plasma; Prevalence; Research; Research Personnel; Resources; Risk Factors; Serum; Source; United States National Institutes of Health; burden of illness; cohort; coronary artery calcification; ethnic difference; ethnic minority population; heart disease risk; mortality; prospective; socioeconomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of type 2 diabetes is significantly higher in ethnic minorities and these individuals are morel likely to get complications from their type 2 diabetes, including kidney disease. Individuals with kidney disease are more likely to have heart disease; the risk profile as well as the disease burden in Mexican Americans with type 2 diabetes mellitus and kidney disease has never been defined. The study is a prospective, observational, cohort study of Mexican Americans and Non Hispanic Whites with diabetic nephropathy. The purpose of this study is to define the baseline atherosclerotic burden ( as assessed by coronary artery calcification) , the rate of progression of atherosclerotic burden and the total as well as cardiovascular mortality in a cohort of Mexican Americans with diabetic nephropathy and compare it to a cohort of non-Hispanic whites with diabetic nephropathy. Furthermore, the contribution of several risk factors for atherosclerosis to explain the ethnic differences in coronary artery calcification burden will be studied. Two emerging factors (plasma homocysteine and serum leptin levels) as well as several socio-economic variables will be studied to determine their contribution to the ethnic differences in coronary artery calcification burden.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 2型糖尿病的患病率在少数民族中明显较高，这些人更容易患2型糖尿病并发症，包括肾脏疾病。患有肾病的人更有可能患有心脏病;患有2型糖尿病和肾病的墨西哥裔美国人的风险状况和疾病负担从未被定义。 该研究是一项针对墨西哥裔美国人和非西班牙裔白人糖尿病肾病患者的前瞻性、观察性、队列研究。本研究的目的是确定基线动脉粥样硬化负荷（通过冠状动脉钙化评估）、动脉粥样硬化负荷进展率以及墨西哥裔美国人糖尿病肾病队列的总死亡率和心血管死亡率，并将其与非西班牙裔白人糖尿病肾病队列进行比较。此外，将研究几个动脉粥样硬化的危险因素对解释冠状动脉钙化负荷的种族差异的贡献。将研究两个新兴因素（血浆同型半胱氨酸和血清瘦素水平）以及几个社会经济变量，以确定其对冠状动脉钙化负荷种族差异的贡献。