A RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL OF CORTICOSTEROID THERAPY

皮质类固醇治疗的随机、双盲、安慰剂对照试验

基本信息

  • 批准号:
    8166708
  • 负责人:
  • 金额:
    $ 0.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-12-01 至 2010-11-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biliary atresia is the most common cause of cholestasis in infants and the most frequent indication for pediatric liver transplantation. The disease results from a destructive inflammatory process that affects intra- and extrahepatic bile ducts, leading to fibrosis and obliteration of the biliary tract. Although little is known about the etiology or pathogenesis of biliary atresia, epidemiologic and virologic studies point to a complex trait disorder, in which environmental factors trigger an inflammatory process that recognizes and abnormally targets the biliary system during a specific phase of postnatal development. Based on these data, the following unifying pathogenesis model can be preliminarily proposed: Regardless of initiating (environmental) and modifying (genetic) factors for disease development, the inflammatory and fibrosing destruction of the biliary epithelium is common to all clinical forms of biliary atresia. In this setting, the potential decrease of this inflammatory component by corticosteroid treatment may result in improved bile flow and better outcome after portoenterostomy. Therefore, in this clinical trial we propose to objectively determine whether corticosteroid treatment improves bile flow in infants with biliary atresia. The significance of the proposed trial is that it will determine whether corticosteroids are an effective medical treatment to improve bile drainage and long-term outcome, and whether its use reduces the need for liver transplantation in infants with biliary atresia. The trial will be performed by the NIH-supported Biliary Atresia Research Consortium (BARC). BARC has the infrastructure to prospectively follow a sufficiently large number of patients and to collect samples necessary for clinical research studies addressing etiology, pathogenesis, diagnosis, and treatment of children with biliary atresia. Our overall hypothesis is that therapy with corticosteroids following portoenterostomy will improve bile drainage and long-term outcome in infants with biliary atresia. This hypothesis will be tested through the following hypotheses:
这个子项目是众多研究子项目之一

项目成果

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SAUL J. KARPEN其他文献

SAUL J. KARPEN的其他文献

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{{ truncateString('SAUL J. KARPEN', 18)}}的其他基金

Modeling genetic contributions to biliary atresia
模拟遗传对胆道闭锁的影响
  • 批准号:
    10639240
  • 财政年份:
    2023
  • 资助金额:
    $ 0.85万
  • 项目类别:
Research Training in Translational Gastroenterology and Hepatology
转化胃肠病学和肝病学研究培训
  • 批准号:
    10410926
  • 财政年份:
    2016
  • 资助金额:
    $ 0.85万
  • 项目类别:
Research Training in Translational Gastroenterology and Hepatology
转化胃肠病学和肝病学研究培训
  • 批准号:
    9073070
  • 财政年份:
    2016
  • 资助金额:
    $ 0.85万
  • 项目类别:
Research Training in Translational Gastroenterology and Hepatology
转化胃肠病学和肝病学研究培训
  • 批准号:
    9280922
  • 财政年份:
    2016
  • 资助金额:
    $ 0.85万
  • 项目类别:
A RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL OF CORTICOSTEROID THERAPY
皮质类固醇治疗的随机、双盲、安慰剂对照试验
  • 批准号:
    8356692
  • 财政年份:
    2010
  • 资助金额:
    $ 0.85万
  • 项目类别:
The Childhood Liver Disease Research and Education Network (ChilDREN)
儿童肝病研究和教育网络 (ChilDREN)
  • 批准号:
    8011891
  • 财政年份:
    2010
  • 资助金额:
    $ 0.85万
  • 项目类别:
CHOLESTATIC LIVER DISEASE CONSORTIUM (CLIC): LONGITUDINAL STUDY OF GENETIC CAUSE
胆汁淤积性肝病联盟 (CLIC):遗传原因的纵向研究
  • 批准号:
    8356694
  • 财政年份:
    2010
  • 资助金额:
    $ 0.85万
  • 项目类别:
BARC: BILLIARY ATRESIA STUDY IN INFANTS AND CHILDREN (BASIC)
BARC:婴儿和儿童胆道闭锁研究(基础)
  • 批准号:
    8356678
  • 财政年份:
    2010
  • 资助金额:
    $ 0.85万
  • 项目类别:
BILIARY ATRESIA RESEARCH CONSORTIUM (BARC): A PROSPECTIVE DATABASE OF INFANT
胆道闭锁研究联盟 (BARC):婴儿前瞻性数据库
  • 批准号:
    8356666
  • 财政年份:
    2010
  • 资助金额:
    $ 0.85万
  • 项目类别:
CHOLESTATIC LIVER DISEASE CONSORTIUM (CLIC): LONGITUDINAL STUDY OF GENETIC CAUSE
胆汁淤积性肝病联盟 (CLIC):遗传原因的纵向研究
  • 批准号:
    8166711
  • 财政年份:
    2009
  • 资助金额:
    $ 0.85万
  • 项目类别:
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