Research Training in Translational Gastroenterology and Hepatology

项目摘要 近年来，胃肠病学和肝病学患者护理的重大进展在很大程度上是由采用动物模型和人类受试者的预防性研究的应用所驱动的。越来越多的基础和临床研究方法的交叉授粉正在产生对胃肠道（GI）和肝脏生物学以及疾病发病机制的新见解。该培训补助金（TG）的主要目标是为优秀的博士后MD，MD/PhD和PhD研究人员在翻译胃肠病学和肝病学方面的成功和有影响力的职业生涯做好准备。培训计划（TP）强调基础生物学和转化医学之间的接口工作，以填补知识的重要空白，并开发有效的治疗方法。TP纳入了在所有阶段拥抱多样性，公平性和包容性的核心目标：候选人宣传，申请人和导师的选择，保留和监督学员，以及选定的受邀演讲者。TP是建立在一个由20名NIH支持的以受训者为中心的导师组成的经验丰富的团队的基础上的（8名来自儿科，9名来自内科，3名来自其他部门）。导师库包括10名主要是基础研究人员，4名主要是临床研究人员，6名研究组合在基础和临床研究之间平均分配。由于许多成人胃肠道和肝脏疾病起源于儿童时期，通常持续一生，因此包括成人和儿科亚专业的导师。这个TG应用程序的重点是每年招收2名博士后培训生（MD，MD/PhD或PhD）。培训生发展专业知识，并提供反馈，作为TP执行委员会和导师的监督和指导下的消化健康研究人员，整合内部和外部咨询委员会的投入。对于那些谁将从高级学位受益，TP是通过兰尼研究生院/格鲁吉亚临床和转化科学联盟纳入了在临床研究或转化研究证书课程理学硕士结构化学位课程。学员受益于一个平衡的奖学金监督委员会，具有基本和翻译专业知识，负责研究行为（RCR）培训的课程和学员驱动的个人发展计划（IDP）。通过TP的充实计划，在教育和职业发展的谈话和研讨会文化中完成个性化TP（课程，指导研究经验，环境暴露，建议和专业发展），为学员的职业生涯提供丰富而持久的跳板。

Project Summary In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) emphasizes work at the interface between basic biology and translational medicine in order to fill important gaps in knowledge and develop effective therapeutics. The TP incorporates core goals of embracing diversity, equity and inclusivity at all stages: candidacy outreach, applicant and mentor selection, retention and oversight of trainees, and selected invited speakers. The TP is built upon the strengths of a highly experienced group of 20 NIH-supported trainee-focused mentors (8 from Pediatrics, 9 from Internal Medicine, and 3 from other Departments). The mentor pool consists of 10 of whom are primarily basic researchers, 4 principally clinical researchers, and 6 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are included. This TG application focuses efforts on enrolling 2 post-doctoral Trainees (MD, MD/PhD or PhD) each year. Trainees develop expertise and provide feedback as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. For those who will benefit from advanced degrees, the TP is incorporates a structured degree program in Masters of Science in Clinical Research or a Certificate Program in Translational Research via the Laney Graduate School/Georgia Clinical and Translational Science Alliance. Mentees benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) within a culture of talks and symposia for education and career development via the Enrichment Program of the TP, provide a rich and lasting springboard for mentees' careers.