Research Training in Translational Gastroenterology and Hepatology

项目摘要 近年来，胃肠病学和肝脏学在病人护理方面的重大进步在很大程度上是由采用动物模型和人类受试者的面向翻译的研究的应用推动的。基础和临床研究方法的交叉授粉越来越多地产生了对胃肠道(GI)和肝脏生物学以及疾病发病机制的新见解。该培训基金(TG)的总体目标是培养优秀的博士后、医学博士/博士和博士后研究人员，以便在翻译胃肠病学和肝脏病学领域取得成功和有影响力的职业生涯。培训计划(TP)强调在基础生物学和转化医学之间的接口工作，以填补重要的知识空白和开发有效的治疗方法。TP在所有阶段纳入了包容多样性、公平和包容性的核心目标：候选人资格宣传、申请者和导师的选择、对受训人员的留住和监督以及选定的特邀演讲者。TP是建立在一个由20名由NIH支持的以学员为重点的导师组成的经验丰富的团队的基础上的(8名来自儿科，9名来自内科，3名来自其他部门)。导师库由10人组成，其中10人主要是基础研究人员，4人主要是临床研究人员，6人的研究组合平均分配给基础和临床研究。由于许多成人的胃肠道疾病和肝脏疾病都起源于童年，通常会延续到一生，因此成人和儿科专科的导师都被包括在内。这项TG申请的重点是每年招收2名博士后实习生(MD、MD/PhD或PhD)。受训人员在TP执行委员会和导师的监督和指导下，结合内部和外部咨询委员会的意见，作为消化健康研究人员发展专业知识并提供反馈。对于那些将受益于高级学位的人，TP IS通过莱尼研究生院/佐治亚州临床和翻译科学联盟纳入了临床研究理学硕士的结构化学位课程或翻译研究证书课程。学员受益于一个具有基本和翻译专业知识的均衡奖学金监督委员会、负责任的研究行为(RCR)培训课程和学员主导的个人发展计划(IDP)。完成个性化的TP(课程作业、指导研究经验、环境暴露、建议和专业发展)，通过TP丰富计划，在教育和职业发展的演讲和研讨会文化中，为学员的职业生涯提供丰富和持久的跳板。

Project Summary In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) emphasizes work at the interface between basic biology and translational medicine in order to fill important gaps in knowledge and develop effective therapeutics. The TP incorporates core goals of embracing diversity, equity and inclusivity at all stages: candidacy outreach, applicant and mentor selection, retention and oversight of trainees, and selected invited speakers. The TP is built upon the strengths of a highly experienced group of 20 NIH-supported trainee-focused mentors (8 from Pediatrics, 9 from Internal Medicine, and 3 from other Departments). The mentor pool consists of 10 of whom are primarily basic researchers, 4 principally clinical researchers, and 6 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are included. This TG application focuses efforts on enrolling 2 post-doctoral Trainees (MD, MD/PhD or PhD) each year. Trainees develop expertise and provide feedback as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. For those who will benefit from advanced degrees, the TP is incorporates a structured degree program in Masters of Science in Clinical Research or a Certificate Program in Translational Research via the Laney Graduate School/Georgia Clinical and Translational Science Alliance. Mentees benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) within a culture of talks and symposia for education and career development via the Enrichment Program of the TP, provide a rich and lasting springboard for mentees' careers.