Research Training in Translational Gastroenterology and Hepatology

转化胃肠病学和肝病学研究培训

基本信息

  • 批准号:
    9280922
  • 负责人:
  • 金额:
    $ 29.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-01 至 2021-05-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. This is due in part to the application of Big Data including the use of next generation sequencing, proteomics, metabolomics, and systems biology. However major gaps and challenges exist. In order to build on these successes in areas such as inflammatory bowel disease (IBD), nonalcoholic steatohepatitis (NASH), cholestasis and neurogastroenterology, the next generation of researchers must be properly prepared to take advantage of these technologies and translational opportunities. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) will emphasize working at the interface between basic biology and translational medicine to fill important gaps in knowledge and therapeutics. The TP is built upon the strengths of a highly-vetted core of 13 experienced NIH-supported mentors (6 from Pediatrics, 3 from Internal Medicine, and 4 from other Departments), 8 of whom are primarily basic researchers, 3 exclusively clinical researchers, and 2 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are purposefully included. Opportunities to access large multi-center longitudinal studies (NIDDK and non-NIDDK-supported) of children and adults with GI and liver diseases have never been more robust or available, and the leadership for the largest of these in IBD, cholestasis and NASH are TG mentors. This TG application will focus efforts on 2 post-doctoral Trainees (MD or PhD) contemporaneously each year. Trainees will develop expertise as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. The TP incorporates a structured degree program in Masters of Science in Clinical Research for one clinically-oriented MD trainee each year, or a Certificate in Translational Research for basic research MD and PhD trainees, via the Laney Graduate School/Atlanta Clinical and Translational Science Institute (ACTSI). Mentees will benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) is expected to provide a rich and lasting springboard for mentees' careers.


项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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SAUL J. KARPEN其他文献

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{{ truncateString('SAUL J. KARPEN', 18)}}的其他基金

Modeling genetic contributions to biliary atresia
模拟遗传对胆道闭锁的影响
  • 批准号:
    10639240
  • 财政年份:
    2023
  • 资助金额:
    $ 29.23万
  • 项目类别:
Research Training in Translational Gastroenterology and Hepatology
转化胃肠病学和肝病学研究培训
  • 批准号:
    10410926
  • 财政年份:
    2016
  • 资助金额:
    $ 29.23万
  • 项目类别:
Research Training in Translational Gastroenterology and Hepatology
转化胃肠病学和肝病学研究培训
  • 批准号:
    9073070
  • 财政年份:
    2016
  • 资助金额:
    $ 29.23万
  • 项目类别:
A RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL OF CORTICOSTEROID THERAPY
皮质类固醇治疗的随机、双盲、安慰剂对照试验
  • 批准号:
    8356692
  • 财政年份:
    2010
  • 资助金额:
    $ 29.23万
  • 项目类别:
The Childhood Liver Disease Research and Education Network (ChilDREN)
儿童肝病研究和教育网络 (ChilDREN)
  • 批准号:
    8011891
  • 财政年份:
    2010
  • 资助金额:
    $ 29.23万
  • 项目类别:
CHOLESTATIC LIVER DISEASE CONSORTIUM (CLIC): LONGITUDINAL STUDY OF GENETIC CAUSE
胆汁淤积性肝病联盟 (CLIC):遗传原因的纵向研究
  • 批准号:
    8356694
  • 财政年份:
    2010
  • 资助金额:
    $ 29.23万
  • 项目类别:
BARC: BILLIARY ATRESIA STUDY IN INFANTS AND CHILDREN (BASIC)
BARC:婴儿和儿童胆道闭锁研究(基础)
  • 批准号:
    8356678
  • 财政年份:
    2010
  • 资助金额:
    $ 29.23万
  • 项目类别:
BILIARY ATRESIA RESEARCH CONSORTIUM (BARC): A PROSPECTIVE DATABASE OF INFANT
胆道闭锁研究联盟 (BARC):婴儿前瞻性数据库
  • 批准号:
    8356666
  • 财政年份:
    2010
  • 资助金额:
    $ 29.23万
  • 项目类别:
A RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL OF CORTICOSTEROID THERAPY
皮质类固醇治疗的随机、双盲、安慰剂对照试验
  • 批准号:
    8166708
  • 财政年份:
    2009
  • 资助金额:
    $ 29.23万
  • 项目类别:
CHOLESTATIC LIVER DISEASE CONSORTIUM (CLIC): LONGITUDINAL STUDY OF GENETIC CAUSE
胆汁淤积性肝病联盟 (CLIC):遗传原因的纵向研究
  • 批准号:
    8166711
  • 财政年份:
    2009
  • 资助金额:
    $ 29.23万
  • 项目类别:

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胃肠病学和肝病学多学科研究培训
  • 批准号:
    9922266
  • 财政年份:
    2019
  • 资助金额:
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  • 项目类别:
Multidisciplinary Research Training in Gastroenterology and Hepatology
胃肠病学和肝病学多学科研究培训
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  • 财政年份:
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  • 项目类别:
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  • 批准号:
    10612780
  • 财政年份:
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Multidisciplinary Research Training in Gastroenterology and Hepatology
胃肠病学和肝病学多学科研究培训
  • 批准号:
    10632345
  • 财政年份:
    2019
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    $ 29.23万
  • 项目类别:
Multidisciplinary Research Training in Gastroenterology and Hepatology
胃肠病学和肝病学多学科研究培训
  • 批准号:
    10621459
  • 财政年份:
    2019
  • 资助金额:
    $ 29.23万
  • 项目类别:
Multidisciplinary Research Training in Gastroenterology and Hepatology
胃肠病学和肝病学多学科研究培训
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  • 财政年份:
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胃肠病学和肝病学转化研究培训
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    9906212
  • 财政年份:
    2018
  • 资助金额:
    $ 29.23万
  • 项目类别:
Translational Research Training in Gastroenterology and Hepatology
胃肠病学和肝病学转化研究培训
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  • 财政年份:
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转化胃肠病学和肝病学研究培训
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转化胃肠病学和肝病学研究培训
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    2016
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