Research Training in Translational Gastroenterology and Hepatology

转化胃肠病学和肝病学研究培训

• 批准号: 9280922
• 负责人: SAUL J. KARPEN
• 金额: $ 29.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9280922
• 关键词: Gastroenterology; Hepatology; Research Training

 DESCRIPTION (provided by applicant): In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. This is due in part to the application of Big Data including the use of next generation sequencing, proteomics, metabolomics, and systems biology. However major gaps and challenges exist. In order to build on these successes in areas such as inflammatory bowel disease (IBD), nonalcoholic steatohepatitis (NASH), cholestasis and neurogastroenterology, the next generation of researchers must be properly prepared to take advantage of these technologies and translational opportunities. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) will emphasize working at the interface between basic biology and translational medicine to fill important gaps in knowledge and therapeutics. The TP is built upon the strengths of a highly-vetted core of 13 experienced NIH-supported mentors (6 from Pediatrics, 3 from Internal Medicine, and 4 from other Departments), 8 of whom are primarily basic researchers, 3 exclusively clinical researchers, and 2 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are purposefully included. Opportunities to access large multi-center longitudinal studies (NIDDK and non-NIDDK-supported) of children and adults with GI and liver diseases have never been more robust or available, and the leadership for the largest of these in IBD, cholestasis and NASH are TG mentors. This TG application will focus efforts on 2 post-doctoral Trainees (MD or PhD) contemporaneously each year. Trainees will develop expertise as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. The TP incorporates a structured degree program in Masters of Science in Clinical Research for one clinically-oriented MD trainee each year, or a Certificate in Translational Research for basic research MD and PhD trainees, via the Laney Graduate School/Atlanta Clinical and Translational Science Institute (ACTSI). Mentees will benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) is expected to provide a rich and lasting springboard for mentees' careers.

 描述(申请人提供)：近年来，胃肠病学和肝脏病学在患者护理方面的重大进步在很大程度上是由采用动物模型和人类受试者的面向翻译的研究的应用推动的。基础和临床研究方法的交叉授粉越来越多地产生了对胃肠道(GI)和肝脏生物学以及疾病发病机制的新见解。这在一定程度上是由于大数据的应用，包括使用下一代测序、蛋白质组学、代谢组学和系统生物学。然而，仍然存在重大差距和挑战。为了在炎症性肠病(IBD)、非酒精性脂肪性肝炎(NASH)、胆汁淤积症和神经胃肠病等领域取得成功的基础上，下一代研究人员必须做好充分准备，以利用这些技术和翻译机会。该培训基金(TG)的总体目标是培养优秀的博士后、医学博士/博士和博士后研究人员，以便在翻译胃肠病学和肝脏病学领域取得成功和有影响力的职业生涯。培训计划(TP)将强调在基础生物学和转化医学之间的接口工作，以填补知识和治疗方面的重要空白。TP建立在由13名经验丰富的NIH支持的导师(6名来自儿科，3名来自内科，4名来自其他科室)组成的高度审查的核心力量的基础上，其中8人主要是基础研究人员，3人专门从事临床研究，2人的研究组合平均分配给基础研究和临床研究。由于许多成人的胃肠道疾病和肝病都起源于童年，通常会延续到一生，因此有目的地将成人和儿科专科的导师包括在内。获得对患有胃肠道疾病和肝病的儿童和成人的大型多中心纵向研究(NIDDK和非NIDDK支持的研究)的机会从未像现在这样强大或可用，其中最大的IBD、胆汁淤积症和NASH的领导者是TG导师。这个TG应用程序将集中精力每年同时招收2名博士后实习生(医学博士或博士研究生)。学员将在TP执行委员会和导师的监督和指导下，结合内部和外部咨询委员会的意见，发展作为消化健康研究人员的专业知识。TP通过莱尼研究生院/亚特兰大临床和翻译科学研究所(ACTSI)，每年为一名面向临床的MD实习生提供结构化的临床研究理学硕士学位课程，或为基础研究MD和博士实习生提供翻译研究证书。受训者将受益于一个具有基本和翻译专业知识的平衡奖学金监督委员会、负责任的研究行为(RCR)培训课程和受训者驱动的个人发展计划(IDP)。完成个性化的TP(课程作业、指导研究经验、环境暴露、建议和专业发展)预计将为学员的职业生涯提供丰富和持久的跳板。