Research Training in Translational Gastroenterology and Hepatology

转化胃肠病学和肝病学研究培训

• 批准号: 9280922
• 负责人: SAUL J. KARPEN
• 金额: $ 29.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9280922
• 关键词: Gastroenterology; Hepatology; Research Training

 DESCRIPTION (provided by applicant): In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. This is due in part to the application of Big Data including the use of next generation sequencing, proteomics, metabolomics, and systems biology. However major gaps and challenges exist. In order to build on these successes in areas such as inflammatory bowel disease (IBD), nonalcoholic steatohepatitis (NASH), cholestasis and neurogastroenterology, the next generation of researchers must be properly prepared to take advantage of these technologies and translational opportunities. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) will emphasize working at the interface between basic biology and translational medicine to fill important gaps in knowledge and therapeutics. The TP is built upon the strengths of a highly-vetted core of 13 experienced NIH-supported mentors (6 from Pediatrics, 3 from Internal Medicine, and 4 from other Departments), 8 of whom are primarily basic researchers, 3 exclusively clinical researchers, and 2 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are purposefully included. Opportunities to access large multi-center longitudinal studies (NIDDK and non-NIDDK-supported) of children and adults with GI and liver diseases have never been more robust or available, and the leadership for the largest of these in IBD, cholestasis and NASH are TG mentors. This TG application will focus efforts on 2 post-doctoral Trainees (MD or PhD) contemporaneously each year. Trainees will develop expertise as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. The TP incorporates a structured degree program in Masters of Science in Clinical Research for one clinically-oriented MD trainee each year, or a Certificate in Translational Research for basic research MD and PhD trainees, via the Laney Graduate School/Atlanta Clinical and Translational Science Institute (ACTSI). Mentees will benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) is expected to provide a rich and lasting springboard for mentees' careers.

 描述（由申请人提供）：近年来，胃肠病学和肝病学患者护理方面的重大进展很大程度上是由采用动物模型和人类受试者的转化型研究的应用推动的。基础和临床研究方法的交叉授粉越来越多地产生了对胃肠道（GI）和肝脏生物学以及疾病发病机制的新见解。这部分归功于大数据的应用，包括下一代测序、蛋白质组学、代谢组学和系统生物学的使用。然而，仍然存在重大差距和挑战。为了在炎症性肠病（IBD）、非酒精性脂肪性肝炎（NASH）、胆汁淤积和神经胃肠病学等领域取得这些成功，下一代研究人员必须做好充分准备，以利用这些技术和转化机会。该培训补助金 (TG) 的总体目标是为杰出的博士后医学博士、医学博士/博士和博士研究人员做好准备，使其在转化胃肠病学和肝病学领域取得成功和有影响力的职业生涯。培训计划（TP）将强调基础生物学和转化医学之间的结合，以填补知识和治疗学方面的重要空白。 TP 建立在 13 名经验丰富的 NIH 支持导师（6 名来自儿科、3 名来自内科、4 名来自其他科室）的严格审查核心优势之上，其中 8 名主要是基础研究人员，3 名完全是临床研究人员，另外 2 名的研究工作在基础研究和临床研究之间平分秋色。由于许多成人胃肠道和肝脏疾病起源于童年，并且往往会持续一生，因此特意邀请了来自成人和儿科亚专业的导师。对患有胃肠道和肝脏疾病的儿童和成人进行大型多中心纵向研究（NIDDK 和非 NIDDK 支持）的机会从未如此强大或可用，其中 IBD、胆汁淤积和 NASH 领域最大的研究的领导者是 TG 导师。该 TG 申请将每年同时集中培养 2 名博士后实习生（医学博士或博士）。学员将在 TP 执行委员会和导师的监督和指导下，结合内部和外部顾问委员会的意见，发展作为消化健康研究人员的专业知识。 TP 每年为一名临床导向的医学博士实习生提供临床研究理学硕士学位的结构化学位课程，或通过莱尼研究生院/亚特兰大临床和转化科学研究所 (ACTSI) 为基础研究医学博士和博士实习生提供转化研究证书。受训者将受益于平衡的奖学金监督委员会，该委员会拥有基础和转化专业知识、负责任的研究行为（RCR）培训课程以及受训者驱动的个人发展计划（IDP）。完成个性化 TP（课程作业、指导研究经验、环境接触、建议和专业发展）预计将为学员的职业生涯提供丰富而持久的跳板。