ALZHEIMER CAREGIVER COPING: MENTAL AND PHYSICAL HEALTH

阿尔茨海默病照护者应对措施：心理和身体健康

• 批准号: 8166783
• 负责人: IGOR GRANT
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166783
• 关键词: Affective; Alzheimer' s Disease; Anxiety; Arousal; Atherosclerosis; Attenuated; Caregiver Burden; Caregivers; Catecholamines; Computer Retrieval of Information on Scientific Projects Database; Exhibits; Fibrin fragment D; Funding; Grant; Inflammatory; Institution; Interleukin-6; Medial; Psyche structure; Research; Research Personnel; Resources; Sleep; Sleep disturbances; Source; Thick; Time; United States National Institutes of Health; beta-adrenergic receptor; blood pressure regulation; cardiovascular disorder risk; cardiovascular injury; caregiving; coping; coping mechanism; depressive symptoms; experience; physical conditioning; receptor density; response; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis A(1). Caregivers, compared to non-caregivers, will experience more symptoms of depression, anxiety, and sleep difficulties (e.g., shorter sleep time, more awakenings, and reduced sleep efficiency). Within caregivers, the greatest affective disturbance and sleep difficulties will be found among the most highly stressed caregivers and those who exhibit maladaptive coping mechanisms (e.g., avoidance, activity restriction, negative appraisals of caregiving). A(2). The indicators of affective arousal and sleep disturbance in A(1) will be associated with increased sympathoadrenal medullary (SAM) tone reflected by higher circulating catecholamines and decreased beta adrenergic receptor density and sensitivity. A mental stressor task will elicit greatest catecholamine response among the most stressed caregivers. A(3). SAM arousal will be associated with increases in basal inflammatory (e.g., IL-6) and procoagulant (e.g., D-dimer) markers that have previously been associated with heightened risk of cardiovascular disease. A mental stressor task will reveal augmented rise in these molecules among the most stressed caregivers. A(4). The markers of SAM arousal noted in A(2) and A(3) will be associated with markers of cardiovascular injury, including disturbed blood pressure regulation, disturbance in endothelial function, and an increase in subclinical atherosclerosis (i.e. increase in carotid intimal medial thickness (CIMT)). A(5) SAM arousal and the hypothesized downstream consequences listed in A(3) and A(4) will be attenuated by positive coping strategies that include mastery and a problem focused approach.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设A（1）。 与非护理人员相比，护理人员将经历更多的抑郁、焦虑和睡眠困难症状（例如，睡眠时间更短，醒来次数更多，睡眠效率降低）。在照顾者中，最大的情感障碍和睡眠困难将在压力最大的照顾者和那些表现出适应不良的应对机制（例如，回避、活动限制、对回避的负面评价）。 A（2）。A（1）中情感唤醒和睡眠障碍的指标将与交感肾上腺髓质（SAM）张力增加相关，其反映为较高的循环儿茶酚胺和降低的β肾上腺素能受体密度和敏感性。精神压力源任务将引起最紧张的照顾者之间的最大的儿茶酚胺反应。 A（3）。SAM唤醒将与基础炎症（例如，IL-6）和促凝血剂（例如，D-二聚体）标记物，这些标记物以前与心血管疾病的高风险相关。精神压力源任务将揭示这些分子在压力最大的照顾者中的增加。 A（4）。A（2）和A（3）中提到的SAM唤醒标志物将与心血管损伤标志物相关，包括血压调节紊乱、内皮功能紊乱和亚临床动脉粥样硬化增加（即颈动脉内膜中层厚度（CIMT）增加）。 A（5）SAM唤醒和A（3）和A（4）中列出的假设的下游后果将通过积极的应对策略（包括掌握和以问题为中心的方法）减弱。