International Core

国际核心

• 批准号: 8054310
• 负责人: IGOR GRANT
• 金额: $ 7.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8054310
• 关键词: AIDS neuropathy; Address; Affect; Anti-Retroviral Agents; Behavioral; Brazil; China; Collaborations; Communication; Consultations; Country; Couples; Data Analyses; Data Collection; Developing Countries; Development; Discipline; English Language; Environment; Epidemic; Epidemiology; Exposure to; Extramural Activities; Funding; Future; Goals; Grant; HIV; HIV Infections; Hepatitis C; Human Genetics; Impairment; Incidence; India; Information Systems; International; International Aspects; Language; Macronutrients Nutrition; Malnutrition; Manuscripts; Mentors; Methods; Micronutrients; Neurocognitive; Neurologic; Nutritional; Other Genetics; Pathogenesis; Pattern; Persons; Pharmaceutical Preparations; Pharmacology; Preparation; Public Health; Research; Research Methodology; Research Personnel; Research Support; Resources; Risk; Romania; Scientist; Site; Source; South Africa; Technology Transfer; Training; United States National Institutes of Health; Validation; Writing; career development; cofactor; data management; design; experience; illiterate; implementation research; improved; interest; literacy; multidisciplinary; neuropsychological; outreach; pathogen; programs; quality assurance; research study; skills; socioeconomics; tool; transmission process; web site

HNRC investigators have rapidly expanded their international focus in recognition of significant research questions and methodological issues pertaining to NeuroAIDS in developing countries. The pertinent scientific questions include how human genetic factors, HIV clade differences, and socioeconomic, cultural, and environment differences (e.g., nutritional deficiencies and exposure to coinfecting pathogens) affect the epidemiology, phenomenology, pathogenesis, and treatment of neuroAIDS. Methodological issues include development of valid assessments of neurocognitive function in non-English language and non-Western cultures, and in illiterate or semiliterate persons. Addition of an International Core to the HNRC is proposed to identify opportunities for international research and to facilitate partnering between HNRC investigators and scientist-clinicians in resource-limited settings to build capacity to undertake neuroAIDS research that is responsive to the needs and circumstances of those settings, guided in each case by the two main principles: 1) public health importance and 2) focused, feasible (pragmatic) partnering. The Core will assist in coordinating scientific consultation, mentoring, and technical assistance designed to develop collaborative, investigator-initiated, fundable international research programs on NeuroAIDS. Examples of collaborations underway in the current review period, which will be expanded and diversified over the next 5 years through the International Core's activities, include the first systematic study of HIV neurocognitive complications in two risk groups in China; a developmental study of NeuroAIDS in Brazil; feasibility assessments for a future study on the incidence and course of neurocognitive impairment in serodiscordant couples in Pune, India and added exploratory discussions with investigators in Romania and South Africa. Alongside its outreach and partnering activities, the International Core also will coordinate resources to promote training in research methodology, experience and skills building in U.S. and foreign scientific administration and regulatory requirements for international research, an international research section of the HNRC web site that consolidates information and facilitates access to resources, a program of on-site training and developmental grants for international colleagues (in coordination with Developmental Core), and improved communications and data management capacity at collaborating international sites.

HNRC调查人员迅速扩大了国际关注范围，以认识到重大的 研究问题和方法问题有关的NeuroAIDS在发展中国家。的 相关的科学问题包括人类遗传因素、艾滋病毒进化枝差异以及 社会经济、文化和环境差异（例如，营养缺乏和暴露于合并感染 病原体）影响神经AIDS的流行病学、现象学、发病机制和治疗。 方法论问题包括发展有效的非英语神经认知功能评估 语言和非西方文化，以及文盲或半文盲的人。增加一个国际 HNRC的核心建议是确定国际研究的机会，并促进伙伴关系 在资源有限的环境中，HNRC调查人员和科学家-临床医生之间进行能力建设， 进行神经艾滋病研究，是响应这些设置的需要和情况，指导 在每一种情况下，由两个主要原则：1）公共卫生的重要性和2）重点突出，可行（务实） 合作核心将协助协调科学咨询、指导和技术援助 旨在开发合作，赞助商发起的，可资助的国际研究计划， 神经艾滋病目前审查期间正在进行的合作的例子，这些合作将扩大， 在未来5年内，通过国际核心的活动，包括第一次系统的研究， 中国两个高危人群中HIV神经认知并发症的发生率; 巴西;未来关于神经认知障碍发病率和病程研究的可行性评估 在印度浦那的血清不一致夫妇中，并与罗马尼亚的研究人员进行了探索性讨论 和南非。除了外联和伙伴关系活动外，国际核心还将 协调资源，以促进在美国的研究方法，经验和技能建设的培训。 和外国科学管理和国际研究的监管要求，一个国际 HNRC网站的研究部分，整合信息并方便访问资源， 为国际同事提供现场培训和发展赠款的计划（与 开发核心），并提高了合作伙伴的通信和数据管理能力。 国际网站。