International Core

HNRC调查人员迅速扩大了他们的国际重点，以认识到重要的 与发展中国家的神经艾滋病有关的研究问题和方法问题。这个 相关的科学问题包括人类遗传因素、艾滋病毒分支的差异以及 社会经济、文化和环境差异(例如，营养不足和接触混合感染 病原体)影响神经艾滋病的流行病学、现象学、发病机制和治疗。 方法学问题包括发展对非英语国家的神经认知功能的有效评估 在语言和非西方文化中，以及在文盲或半文盲中。增加一名国际球员 HNRC的核心建议是确定国际研究的机会，并促进合作 在资源有限的情况下，在HNRC研究人员和科学家-临床医生之间建立能力，以 进行神经艾滋病研究，以适应这些环境的需要和情况，并在指导下 在每个案例中都遵循两个主要原则：1)公共卫生的重要性和2)专注、可行(务实) 合作。核心将协助协调科学咨询、指导和技术援助 旨在开发合作的、由研究人员发起的、可资助的国际研究计划 神经艾滋病。本审查期内正在进行的协作实例，将扩大和 在未来5年通过国际核心的活动实现多样化，包括第一次系统研究 中国地区两个危险人群HIV神经认知并发症的研究 巴西；关于神经认知障碍发生率和病程的未来研究的可行性评估 在印度浦那的血清不一致夫妇中，并增加了与罗马尼亚调查人员的探索性讨论 还有南非。除了其外联和伙伴关系活动外，国际核心组织还将 协调资源，促进在美国的研究方法、经验和技能建设方面的培训。 以及国外科学管理和监管对国际研究的要求，一个国际 HNRC网站的研究部分，它整合信息并促进资源的访问，a 为国际同事提供的现场培训和发展赠款方案(与 开发核心)，并提高了协作方面的通信和数据管理能力 国际网站。

HNRC investigators have rapidly expanded their international focus in recognition of significant research questions and methodological issues pertaining to NeuroAIDS in developing countries. The pertinent scientific questions include how human genetic factors, HIV clade differences, and socioeconomic, cultural, and environment differences (e.g., nutritional deficiencies and exposure to coinfecting pathogens) affect the epidemiology, phenomenology, pathogenesis, and treatment of neuroAIDS. Methodological issues include development of valid assessments of neurocognitive function in non-English language and non-Western cultures, and in illiterate or semiliterate persons. Addition of an International Core to the HNRC is proposed to identify opportunities for international research and to facilitate partnering between HNRC investigators and scientist-clinicians in resource-limited settings to build capacity to undertake neuroAIDS research that is responsive to the needs and circumstances of those settings, guided in each case by the two main principles: 1) public health importance and 2) focused, feasible (pragmatic) partnering. The Core will assist in coordinating scientific consultation, mentoring, and technical assistance designed to develop collaborative, investigator-initiated, fundable international research programs on NeuroAIDS. Examples of collaborations underway in the current review period, which will be expanded and diversified over the next 5 years through the International Core's activities, include the first systematic study of HIV neurocognitive complications in two risk groups in China; a developmental study of NeuroAIDS in Brazil; feasibility assessments for a future study on the incidence and course of neurocognitive impairment in serodiscordant couples in Pune, India and added exploratory discussions with investigators in Romania and South Africa. Alongside its outreach and partnering activities, the International Core also will coordinate resources to promote training in research methodology, experience and skills building in U.S. and foreign scientific administration and regulatory requirements for international research, an international research section of the HNRC web site that consolidates information and facilitates access to resources, a program of on-site training and developmental grants for international colleagues (in coordination with Developmental Core), and improved communications and data management capacity at collaborating international sites.