Coordinating Core

协调核心的主要目标是确保综合、连贯和有效的科学 在HNRC的行动。为了以高效和负责任的方式支持HNRC，协调 核心被组织成四个相互作用的单元。管理单元负责部署中心 资源，协调中心活动，组织中心和每个核心的年度评估， 协调向科学界和普通界传播信息，并确保 HNRC与研究相关的活动完全符合所有大学、州和联邦政策。数据 管理和信息系统股跟踪所有与中心相关的数据，并确保无缝 通过互联网可访问的数据资源系统与外部项目互动，支持国际项目 努力，并维护HNRC网站，用于内部和外部信息传播。统计数字 该股与调查人员协商，并在项目开发的所有阶段提供统计服务， 实施和公布调查结果。参与人应计和留用(PAR)股招聘新的 感兴趣的队列(例如，早期感染病例、老年艾滋病毒成年人)，保持信息丰富的纵向 队列(n=300)，管理潜在目标研究参与者的花名册，根据需要招募他们 与HNRC相关的具体研究，并为HNRC附属公司提供技术和咨询服务 项目。除了作为核心资源提供的服务外，数据管理、统计和PAR 各单位还将开发新的方法来加强其服务。促进其核心功能的发挥 建立了几个工作组。内部小组包括调查委员会(制定政策 并审查科学进展)；研究审查委员会(审查中心资源申请 并提供讨论拟议研究和手稿的论坛)；主任的工作人员(在日常工作中协助-- 中心的日常管理)与其评价委员会(定期审查HNRC的进展 向主任和国家协调委员会提交报告的指标)；以及人类主题委员会(监测人类 主题和IRB问题，特别是保密问题)。外部团体包括科学咨询 委员会(提供对HNRC科学和方案进展的定期独立审查)， 参与者咨询委员会(向主任提供参与者的反馈)，以及社区 咨询委员会(就中心在不同地方的运作提供建议和反馈 社区)。通过这些程序和结构，协调核心确保 真正的多学科研究中心，为国际研究和 培训方面的努力。

The primary objective of the Coordinating Core is to ensure integrated, coherent, and effective scientific operations at the HNRC. To support the HNRC in an efficient and accountable manner, the Coordinating Core is organized into four interacting units. The Administrative Unit is responsible for deploying center resources, coordinating Center activities, organizing the annual evaluations of the Center and each Core, coordinating information dissemination to both the scientific and general communities, and ensuring that HNRC research-related activities are fully compliant with all university, state, and federal policies. The Data Management and Information Systems Unit tracks all Center-related data and ensures seamless interaction with external projects via an Internet-accessible data resource system, supports international efforts, and maintains the HNRC web site for internal and external information dissemination. The Statistics Unit consults with investigators and provides statistical services during all phases of project development, implementation, and publication of findings. The Participant Accrual and Retention (PAR) Unit recruits new cohorts of interest (e.g., early infection cases, older HIV+ adults), maintains an informative longitudinal cohort (n = 300), manages a roster of potential targeted study participants, recruiting them as required for specific HNRC-associated studies, and provides technical and consulting services to HNRC-affiliated projects. In addition to the services provided as core resources, the Data Management, Statistics, and PAR Units will also develop new methods to enhance their services. To facilitate its functioning the Core established several working groups. The internal groups include the Council of Investigators (sets policy and reviews scientific progress); the Research Review Committee (reviews requests for Center resources and provides a forum to discuss proposed studies and manuscripts); the Director's Staff (assists in the dayto- day management of the Center) with its Evaluation Committee (regularly reviews HNRC progress indicators for reports to the Director and COI); and the Human Subjects Committee (monitors Human Subjects and IRB issues, especially confidentiality). The external groups include the Scientific Advisory Board (provides periodic independent review of HNRC scientific and programmatic progress), the Participants Advisory Board (provides feedback from participants to the Director), and the Community Advisory Board (provides advice and feedback on the functioning of the Center in various local communities). Through those processes and structures the Coordinating Core assures the operation of a truly multidisciplinary research center and provides central coordination for international research and training efforts.