California NeuroAIDS Tissue Network

描述(由申请人提供)：这是加州神经艾滋病组织网络(CNTN)的续签申请，以回应RFA-MH-13-070。CNTN今天的首要目标与1998年首次成立时一样：作为一个组织银行资源，由艾滋病毒感染者的CNS尸检材料组成，这些人在生活中具有很好的神经心理学和神经医学特征。全国过渡委员会在实现这一主要目标方面非常成功。到目前为止，我们总共招募了821名参与者，包括303例身体解剖，39,600份血浆，27,500份脑脊液，18,700份血清和5,600份PBMC。对于目前的应用，我们正在重组我们的队列，以最好地针对高优先级病例并从这些病例中获得身体解剖，这些病例与RFA中确定的三个主题优先事项保持一致：a)从中枢神经系统宿主中根除艾滋病毒；b)长期HAART背景下艾滋病毒相关神经认知障碍的机制(HAND)，以及c)艾滋病毒与老龄化。具体地说，我们将针对1)死亡风险最大、2)从事抗逆转录病毒治疗10年以上、年龄超过50岁的艾滋病毒+参与者的持续参与，这将为NNTC资源提供与NIH三个主题优先事项一致的宝贵病例。具体地说，鉴于河滨县超过10%的H1V+患者年龄在65岁或以上，我们将从与棕榈泉艾森豪威尔医疗中心(EMC)的新合作中招募4名年龄较大(65岁以上)的参与者。CNTN是国家神经艾滋病组织联盟(NNTC)的积极参与者，NNTC是由NIH资助的四个神经艾滋病组织银行组成的伙伴关系。CNTN通过以下方式为NNTC做出贡献：1)领导NNTC神经心理学和精神病学小组委员会并监督这些数据的质量保证，2)指导历史抗逆转录病毒收集的方法，3)对共同的NNTC评估和神经病理学方案的完善做出贡献，4)审查和满足NNTC范围的组织和样本要求，以及5)在NNTC指导委员会服务。CNTN将与NNTC密切合作，确保这一用于神经艾滋病研究的特殊国内和国际资源继续取得成功。

DESCRIPTION (provided by applicant): This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to the RFA- MH-13-070. The overarching objective of the CNTN remains the same today as it was when it was first established in 1998: to serve as a tissue bank resource comprised of CNS autopsy material from HIV- infected individuals who are well characterized neuropsychological and neuromedically in life. The CNTN has been very successful in meeting this primary objective. To date, we have enrolled a total of 821 participants, including 303 autopsies, 39,600 aliquots of plasma, 27,500 aliquots of CSF, 18,700 aliquots of serum, and 5,600 aliquots of PBMCs. For the current application, we are restructuring our cohort to best target and obtain autopsies from high priority cases that are aligned with the three thematic priorities identified in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long term HAART, and c) HIV and aging. Specifically, we will target continuation of HIV+ participants who 1) are at greatest risk for death, 2) have been on ART for more than 10 years, and are greater than 50 years of age, which will provide valuable cases to the NNTC resource that are aligned with the NIH three thematic priorities. Specifically, we will recruit a cohort of 4 older (65+ years old) participants from a new collaboration with the Eisenhower Medical Center (EMC) in Palm Springs given that more than 10% H1V+ persons in Riverside County are 65,or older. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. CNTN contributes to the NNTC by: 1) leading the NNTC Neuropsychology and Psychiatry subcommittee and overseeing quality assurance for these data, 2) guiding the methods for historical antiretroviral collection, 3) contributing to the refinement of the common NNTC assessment and neuropathology protocols, 4) providing review and fulfillment of NNTC-wide tissue and sample requests, and 5) serving on the NNTC Steering Committee.. The CNTN will work closely with the NNTC to ensure continued success of this exceptional national and international resource for research on neuroAIDS.