California NeuroAIDS Tissue Network

描述（由申请人提供）：这是针对RFA- MH-13-070的加利福尼亚神经辅助组织网络（CNTN）的更新申请。今天，CNTN的总体目标仍然与1998年成立时一样：作为组织库资源，包括来自艾滋病毒感染者的中枢神经系统尸检材料，这些人在生活中具有良好的神经心理学和神经医学特征。CNTN在实现这一主要目标方面非常成功。迄今为止，我们共招募了821名参与者，包括303例尸检、39600份血浆、27500份脑脊液、18700份血清和5600份pbmc。对于目前的应用，我们正在重组我们的队列，以最好地瞄准并获得与RFA中确定的三个主题优先事项一致的高优先病例的尸检：a)从中枢神经系统库中根除艾滋病毒；b)长期HAART治疗中HIV相关神经认知障碍（HAND）的机制，以及c) HIV与衰老。具体而言，我们将针对以下人群继续进行艾滋病毒阳性参与者：1)死亡风险最大，2)接受抗逆转录病毒治疗超过10年，年龄大于50岁，这将为NNTC资源提供有价值的病例，与NIH的三个主题优先事项保持一致。具体来说，我们将从与棕榈泉艾森豪威尔医疗中心（EMC）的新合作中招募4名年龄较大（65岁以上）的参与者，因为河滨县有超过10%的H1V+患者年龄在65岁以上。CNTN是国家神经艾滋病组织联盟（NNTC）的积极参与者，NNTC是美国国立卫生研究院资助的四个神经艾滋病组织库的合作伙伴关系。CNTN对NNTC的贡献包括：1)领导NNTC神经心理学和精神病学小组委员会并监督这些数据的质量保证，2)指导历史抗逆转录病毒收集的方法，3)促进NNTC共同评估和神经病理学协议的完善，4)提供NNTC范围内组织和样本请求的审查和履行，5)在NNTC指导委员会任职。CNTN将与NNTC密切合作，确保这一特殊的国家和国际资源在神经艾滋病研究方面继续取得成功。

DESCRIPTION (provided by applicant): This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to the RFA- MH-13-070. The overarching objective of the CNTN remains the same today as it was when it was first established in 1998: to serve as a tissue bank resource comprised of CNS autopsy material from HIV- infected individuals who are well characterized neuropsychological and neuromedically in life. The CNTN has been very successful in meeting this primary objective. To date, we have enrolled a total of 821 participants, including 303 autopsies, 39,600 aliquots of plasma, 27,500 aliquots of CSF, 18,700 aliquots of serum, and 5,600 aliquots of PBMCs. For the current application, we are restructuring our cohort to best target and obtain autopsies from high priority cases that are aligned with the three thematic priorities identified in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long term HAART, and c) HIV and aging. Specifically, we will target continuation of HIV+ participants who 1) are at greatest risk for death, 2) have been on ART for more than 10 years, and are greater than 50 years of age, which will provide valuable cases to the NNTC resource that are aligned with the NIH three thematic priorities. Specifically, we will recruit a cohort of 4 older (65+ years old) participants from a new collaboration with the Eisenhower Medical Center (EMC) in Palm Springs given that more than 10% H1V+ persons in Riverside County are 65,or older. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. CNTN contributes to the NNTC by: 1) leading the NNTC Neuropsychology and Psychiatry subcommittee and overseeing quality assurance for these data, 2) guiding the methods for historical antiretroviral collection, 3) contributing to the refinement of the common NNTC assessment and neuropathology protocols, 4) providing review and fulfillment of NNTC-wide tissue and sample requests, and 5) serving on the NNTC Steering Committee.. The CNTN will work closely with the NNTC to ensure continued success of this exceptional national and international resource for research on neuroAIDS.