Center for Experimental Infectious Disease Research

描述(由申请人提供)：本项目的总体目标是在上一次资助期间取得的重大成就的基础上，继续努力建立一个实验传染病研究中心(CEIDR)，该中心由路易斯安那州立大学巴吞鲁日兽医学院(LSU-BR)领导，与杜兰国家灵长类动物研究中心(TNPRC)和LSU-BR基础科学学院(BASC)结成战略联盟。在上一个供资期间(2003-2008年)招聘的初级调查员的成就包括授予4R01、2R21、2K22、1K01和1个NIH-R01分包合同，以及来自NIH以外来源的竞争性资金。两个新的JL非常接近由ROI拨款资助。重要的是，这些机构获得了NIH T32兽医博士后培训补助金和NIH T35兽医学生暑期培训补助金。科布雷将由NIH资助的高级调查人员管理。K.G.Kousoulas博士(LSU-支持向量机)和A.A.Lackner博士(TNPRC)。Cobre拟议的第6-10年计划包括四个综合研究项目，由从事传染病工作的新的初级调查人员指导。这些新项目是：1.结核分枝杆菌(MTB)免疫病理学的宿主介体(Deepak Kaushal；TNPRC)；2.疏螺旋体逃避先天免疫和获得性免疫(方庭梁，支持向量机)；3.立克次体病原体的分子决定因素(Kevin Macaluso，支持向量机)；4)体液免疫反应在控制SIV复制和致病中的作用(Bapi Pahar，TNPRC)。分子免疫病理学(MIP)核心实验室将作为现有LSU-支持向量机中央实验室的联盟，加强研究基础设施。个别JLS将由三名NIH经验丰富的资深导师指导，他们共同组成该中心的内部咨询委员会(LAC)。该中心的未来发展将通过在未来三年内在路易斯安那州立大学和国家核电研究中心增加4-6名新的调查员以及雇用两名高级调查员来实现。预计研究成果将转化为疫苗和其他治疗方式，以改善人类和动物疾病。 公共卫生相关性(由申请者提供)：拟议的研究重点是寻找新的方法来了解和抗击传染病，包括艾滋病、莱姆病、结核病和蚊媒疾病。这项工作将产生新的诊断方法和疫苗来改善这些疾病。

DESCRIPTION (provided by applicant): The overall objective for this COBRE is to build upon the substantial accomplishments of the previous funding period and continue efforts toward establishing a Center for Experimental Infectious Disease Research (CEIDR) led by the Louisiana State University-Baton Rouge (LSU-BR) School of Veterinary Medicine, (SVM) in a strategic alliance with the Tulane National Primate Research Center (TNPRC) and the LSU-BR College of Basic Sciences (BASC). Accomplishments by junior investigators (Jls) recruited during the last funding period (2003-2008) includes the award of 4R01, 2R21, 2K22,1K01 and 1 NIH-R01- subcontract, as well as competitive funding from sources other than NIH. Two new Jls are very close to be funded with ROI grants. Importantly, the institutions were awarded a NIH T32 postdoctoral training grant for veterinarians and a NIH T35 summer training grant for veterinary students. The COBRE will be administered by senior NIH funded investigators. Dr. K. G. Kousoulas (LSU-SVM) and Dr. A. A. Lackner, (TNPRC). The proposed program for years 6-10 of the COBRE encompass four integrated research projects under the direction of new junior investigators working on infectious diseases. The new projects are; 1. Host mediators of mycobacterium tuberculosis (MTB) immunopathology (Deepak Kaushal; TNPRC); 2. Borrelial evasion of innate and adaptive immunity (Fangting Liang, SVM); 3. Molecular determinants of rickettsial pathogens in tick hosts (Kevin Macaluso, SVM); 4) The role of humoral immune responses in control of SIV replication and pathogenesis (Bapi Pahar, TNPRC). Enhancement ofthe research infrastructure will be achieved by the formation of a Molecular Immunopathology (MIP) Core Laboratory as a consortium of existing LSU-SVM Centralized Laboratories. Individual Jls will be mentored by three NIH-experienced senior mentors who collectively will constitute the internal advisory committee (lAC) of the Center. Future development of the Center will be achieved through the addition of 4-6 new investigators at LSU and TNPRC within the next three years, as well as the hiring of two senior investigators. It is anticipated that research outcomes will be translated to vaccines and other treatment modalities for ameliorating human and animal diseases. PUBLIC HEALTH RELEVANCE (provided by applicant): The proposed research is focused on finding new ways to understand and combat infectious diseases including AIDS, Lyme disease, Tuberculosis and mosquito borne diseases. The work will produce new diagnostics and vaccines to ameliorate these diseases.