Center for Experimental Infectious Disease Research

描述（由申请人提供）：本COBRE的总体目标是建立在前一个资助期取得的实质性成就的基础上，并继续努力建立一个由路易斯安那州立大学巴吞鲁日分校（LSU-BR）兽医学院（SVM）领导的实验性传染病研究中心（CEIDR），与杜兰国家灵长类动物研究中心（TNPRC）和LSU-BR基础科学学院（BASC）建立战略联盟。在上一个资助期（2003-2008）招募的初级研究人员（Jls）的成就包括授予4R01, 2R21, 2K22,1K01和1个NIH- r01 -分包合同，以及来自NIH以外来源的竞争性资助。两个新的Jls非常接近获得ROI拨款。重要的是，这些机构获得了NIH T32兽医博士后培训资助和NIH T35兽医学生暑期培训资助。COBRE将由NIH资助的高级调查人员管理。K. G. Kousoulas博士（LSU-SVM）和A. A. Lackner博士（TNPRC）。COBRE 6-10年的拟议方案包括在从事传染病研究的新初级调查员的指导下进行的四个综合研究项目。新项目有；1. 结核分枝杆菌（MTB）免疫病理宿主介质（TNPRC）；2. 先天性免疫和适应性免疫的疏螺旋体逃避（梁芳婷，SVM）；3. 蜱宿主中立克次体病原体的分子决定因素（Kevin Macaluso， SVM）；4)体液免疫反应在控制SIV复制和发病机制中的作用（Bapi Pahar， TNPRC）。加强研究基础设施将通过形成分子免疫病理学（MIP）核心实验室作为现有LSU-SVM集中实验室的联盟来实现。三位在美国国立卫生研究院经验丰富的资深导师将指导每位Jls，他们将共同组成中心的内部咨询委员会（lAC）。中心未来的发展将通过在未来三年内在路易斯安那州立大学和TNPRC增加4-6名新研究员，以及雇用两名高级研究员来实现。预计研究成果将转化为疫苗和其他治疗方式，以改善人类和动物疾病。

DESCRIPTION (provided by applicant): The overall objective for this COBRE is to build upon the substantial accomplishments of the previous funding period and continue efforts toward establishing a Center for Experimental Infectious Disease Research (CEIDR) led by the Louisiana State University-Baton Rouge (LSU-BR) School of Veterinary Medicine, (SVM) in a strategic alliance with the Tulane National Primate Research Center (TNPRC) and the LSU-BR College of Basic Sciences (BASC). Accomplishments by junior investigators (Jls) recruited during the last funding period (2003-2008) includes the award of 4R01, 2R21, 2K22,1K01 and 1 NIH-R01- subcontract, as well as competitive funding from sources other than NIH. Two new Jls are very close to be funded with ROI grants. Importantly, the institutions were awarded a NIH T32 postdoctoral training grant for veterinarians and a NIH T35 summer training grant for veterinary students. The COBRE will be administered by senior NIH funded investigators. Dr. K. G. Kousoulas (LSU-SVM) and Dr. A. A. Lackner, (TNPRC). The proposed program for years 6-10 of the COBRE encompass four integrated research projects under the direction of new junior investigators working on infectious diseases. The new projects are; 1. Host mediators of mycobacterium tuberculosis (MTB) immunopathology (Deepak Kaushal; TNPRC); 2. Borrelial evasion of innate and adaptive immunity (Fangting Liang, SVM); 3. Molecular determinants of rickettsial pathogens in tick hosts (Kevin Macaluso, SVM); 4) The role of humoral immune responses in control of SIV replication and pathogenesis (Bapi Pahar, TNPRC). Enhancement ofthe research infrastructure will be achieved by the formation of a Molecular Immunopathology (MIP) Core Laboratory as a consortium of existing LSU-SVM Centralized Laboratories. Individual Jls will be mentored by three NIH-experienced senior mentors who collectively will constitute the internal advisory committee (lAC) of the Center. Future development of the Center will be achieved through the addition of 4-6 new investigators at LSU and TNPRC within the next three years, as well as the hiring of two senior investigators. It is anticipated that research outcomes will be translated to vaccines and other treatment modalities for ameliorating human and animal diseases. PUBLIC HEALTH RELEVANCE (provided by applicant): The proposed research is focused on finding new ways to understand and combat infectious diseases including AIDS, Lyme disease, Tuberculosis and mosquito borne diseases. The work will produce new diagnostics and vaccines to ameliorate these diseases.