Center for Experimental Infectious Disease Research

实验传染病研究中心

• 批准号: 7268977
• 负责人: Konstantin G Kousoulas
• 金额: $ 192.42万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7268977
• 关键词: Center; Experimental; Infectious; Disease; Research

DESCRIPTION (provided by applicant): This grant application focuses on the establishment of a Louisiana Center of Biomedical Research Excellence (COBRE) in Experimental Infectious Disease Research (CEIDR) at the Louisiana State University, School of Veterinary Medicine (LSUSVM). This Center will become the focal point of university-wide efforts for the development of nationally competitive scientists in immunity and pathogenesis of infectious diseases. The proposed COBRE represents a strategic alliance between the LSU SVM, the LSU College of Basic Sciences (CBS) and the Tulane National Primate Research Center (TNPRC). The COBRE will be administered by Dr. K. G. Kousoulas (Principal Investigator, LSU). The initial phase of the proposed program encompasses five integrated research projects under the overall umbrella of molecular and immunological aspects of viral infections. Subsequent phases of the Center will include additional projects and investigators working on bacterial and parasitic organisms as well as virology. Hallmarks of the proposed program include senior faculty mentoring junior faculty as co-investigators as well as multidisciplinary mentoring and external advisory committees ensuring success of the overall program. The selected junior investigators (SJIs) are tenure track assistant professors. The individual projects involve molecular virological as well as pathogenetic and immunological aspects of human immunodeficiency virus (HIV), Simian Immunodeficiency Virus (SIV), mouse retrovirus, measles virus and respiratory syncytial virus (RSV). Experimental approaches range from basic virological studies in cell culture to direct experimentation in mice and rhesus macaques to delineate pathogenetic profiles and immune responses of viral infections. Enhancement of the research infrastructure and support of the five research projects will be achieved by the creation of two core laboratories. A Molecular Biology/Immunology Core (MBCL) will be situated at the LSUSVM and will provide molecular biological expertise including real-time PCR and microarray processing, analysis and bioinformatics. In addition, this Core will assist individual investigators in the implementation of molecular/immunological assays. A Non- Human Primate Laboratory Core (NHPCL) will be housed at the TNPRC and will provide expertise in animal related research needs as well as in the characterization of immunological parameters of immunized nonhuman primates. A local mentoring committee will consist of senior scientists with expertise in virology an immunobiology. An external advisory committee will consist of five out-of-state internationally recognized expert scientists in infectious diseases. Future development of the COBRE will be achieved through the addition of 3-5 new investigators recruited from the participating institutions. A significant financial commitment has been made to ensure the success of the program.

描述(由申请人提供)：这项拨款申请的重点是在路易斯安那州立大学兽医学院(LSUSVM)建立路易斯安那州生物医学研究卓越中心(COBRE)的实验传染病研究(CEIDR)。该中心将成为全校努力培养在免疫和传染病发病机制方面具有全国竞争力的科学家的中心。拟议的Cobre代表了路易斯安那州立大学支持向量机、路易斯安那州立大学基础科学学院(CBS)和杜兰国家灵长类研究中心(TNPRC)之间的战略联盟。科布雷将由K.G.Kousoulas博士(路易斯安那州立大学首席调查员)管理。拟议计划的初始阶段包括病毒感染的分子和免疫学方面的总体保护伞下的五个综合研究项目。该中心的后续阶段将包括研究细菌和寄生虫以及病毒学的更多项目和调查人员。拟议项目的特点包括高级教师作为联合调查员指导初级教师，以及多学科指导和外部咨询委员会，以确保整个项目的成功。选定的初级调查人员(SJI)是终身教职跟踪助理教授。个别项目涉及人类免疫缺陷病毒(HIV)、猿猴免疫缺陷病毒(SIV)、小鼠逆转录病毒、麻疹病毒和呼吸道合胞病毒(RSV)的分子病毒学以及病原学和免疫学方面。实验方法从细胞培养中的基本病毒学研究到在小鼠和猕猴身上直接实验，以描绘病毒感染的病原学特征和免疫反应。将通过建立两个核心实验室来加强研究基础设施和支持五个研究项目。分子生物学/免疫学核心(MBCL)将设在LSUSVM，并将提供分子生物学专业知识，包括实时聚合酶链式反应和微阵列处理、分析和生物信息学。此外，这一核心将协助个别调查人员实施分子/免疫分析。非人灵长类实验室核心(NHPCL)将设在TNPRC，将提供与动物相关的研究需求以及免疫非人灵长类免疫参数表征方面的专业知识。当地的一个指导委员会将由在病毒学和免疫生物学方面具有专业知识的资深科学家组成。一个外部咨询委员会将由五名州外的国际公认的传染病专家科学家组成。COBRE的未来发展将通过从参与机构招聘3-5名新的调查员来实现。为了确保该计划的成功，已经做出了重大的财政承诺。