Center for Experimental Infectious Disease Research

描述（由申请人提供）：本资助申请的重点是在路易斯安那州州立大学兽医学院（LSUSVM）建立路易斯安那州实验传染病研究卓越生物医学研究中心（COBRE）。该中心将成为全大学努力培养具有国家竞争力的传染病免疫和发病机制科学家的焦点。拟议中的COBRE代表了LSU SVM，LSU基础科学学院（CBS）和杜兰国家灵长类动物研究中心（TNPRC）之间的战略联盟。COBRE将由K博士管理。G. Kousoulas（路易斯安那州立大学首席研究员）。该计划的初始阶段包括五个综合研究项目，涉及病毒感染的分子和免疫学方面。该中心的后续阶段将包括细菌和寄生生物以及病毒学方面的其他项目和研究人员。拟议计划的特点包括高级教师指导初级教师作为共同调查员，以及多学科的指导和外部咨询委员会，确保整个计划的成功。选定的初级研究员（SJIs）是终身助理教授。个别项目涉及人体免疫机能丧失病毒（艾滋病毒）、猿猴免疫机能丧失病毒（SIV）、小鼠逆转录病毒、麻疹病毒和呼吸道合胞病毒的分子病毒学以及致病和免疫方面。实验方法的范围从细胞培养中的基础病毒学研究到在小鼠和恒河猴中的直接实验，以描绘病毒感染的致病特征和免疫应答。将通过建立两个核心实验室来加强研究基础设施和支持五个研究项目。分子生物学/免疫学核心（MBCL）将位于LSUSVM，并将提供分子生物学专业知识，包括实时PCR和微阵列处理，分析和生物信息学。此外，该核心将协助个体研究者实施分子/免疫学检测。非人灵长类动物实验室核心（NHPCL）将设在TNPRC，并将提供动物相关研究需求以及免疫非人灵长类动物免疫学参数表征方面的专业知识。当地的指导委员会将由具有病毒学和免疫生物学专业知识的资深科学家组成。一个外部咨询委员会将由五名州外国际公认的传染病专家科学家组成。COBRE的未来发展将通过从参与机构招募3-5名新研究者来实现。为确保该方案的成功，已经作出了重大的财政承诺。

DESCRIPTION (provided by applicant): This grant application focuses on the establishment of a Louisiana Center of Biomedical Research Excellence (COBRE) in Experimental Infectious Disease Research (CEIDR) at the Louisiana State University, School of Veterinary Medicine (LSUSVM). This Center will become the focal point of university-wide efforts for the development of nationally competitive scientists in immunity and pathogenesis of infectious diseases. The proposed COBRE represents a strategic alliance between the LSU SVM, the LSU College of Basic Sciences (CBS) and the Tulane National Primate Research Center (TNPRC). The COBRE will be administered by Dr. K. G. Kousoulas (Principal Investigator, LSU). The initial phase of the proposed program encompasses five integrated research projects under the overall umbrella of molecular and immunological aspects of viral infections. Subsequent phases of the Center will include additional projects and investigators working on bacterial and parasitic organisms as well as virology. Hallmarks of the proposed program include senior faculty mentoring junior faculty as co-investigators as well as multidisciplinary mentoring and external advisory committees ensuring success of the overall program. The selected junior investigators (SJIs) are tenure track assistant professors. The individual projects involve molecular virological as well as pathogenetic and immunological aspects of human immunodeficiency virus (HIV), Simian Immunodeficiency Virus (SIV), mouse retrovirus, measles virus and respiratory syncytial virus (RSV). Experimental approaches range from basic virological studies in cell culture to direct experimentation in mice and rhesus macaques to delineate pathogenetic profiles and immune responses of viral infections. Enhancement of the research infrastructure and support of the five research projects will be achieved by the creation of two core laboratories. A Molecular Biology/Immunology Core (MBCL) will be situated at the LSUSVM and will provide molecular biological expertise including real-time PCR and microarray processing, analysis and bioinformatics. In addition, this Core will assist individual investigators in the implementation of molecular/immunological assays. A Non- Human Primate Laboratory Core (NHPCL) will be housed at the TNPRC and will provide expertise in animal related research needs as well as in the characterization of immunological parameters of immunized nonhuman primates. A local mentoring committee will consist of senior scientists with expertise in virology an immunobiology. An external advisory committee will consist of five out-of-state internationally recognized expert scientists in infectious diseases. Future development of the COBRE will be achieved through the addition of 3-5 new investigators recruited from the participating institutions. A significant financial commitment has been made to ensure the success of the program.