ADMINISTRATIVE CORE AND ENRICHMENT PROGRAM

华盛顿大学DDRCC与NIH临床转化科学奖相结合 （CTSA）赞助华盛顿大学临床转化科学研究所（ICTS），主要通过 DDRCC的临床部分和ICTS生物医学信息学中心。DDRCC临床 组件主要侧重于为研究者提供临床样本， 疾病相关的研究。与纵向临床相关的临床样本的收集和维护 以响应我们DDRCC调查人员的方式提供信息，需要高水平的临床 在准确分型患者受试者方面的专业知识和在收集过程中的高水平严格监督 临床样本。出于这个原因，该机构的组织采购已经从一个 一个单一的单一机构单位，试图收集广泛的临床样本的患者， 许多不同的疾病。相反，组织采购是由较小的疾病重点单位进行， 例如DDRCC赞助的设施，这些设施通过共同的生物医学信息学相互联系 由CTSA申办的中心开发和维护的平台（Tissue Suite和ClinPortal）， 生物医学信息学。此外，来自两个研究核心设施的数据输出， Genomics Core和Proteomics Core正在上传到数据库（Profile DB） 由ICTS生物医学信息学中心维护。

The Washington University DDRCC is integrated with the NIH's Clinical Translational Science Award (CTSA) sponsored Washington University Institute of Clinical Translational Sciences (ICTS), primarily through the Clinical Component ofthe DDRCC and the ICTS Centerfor Biomedical Informatics. The DDRCC Clinical Component is primarily focused on providing investigators with access to clinical samples for digestive diseases related research. The collection and maintenance of clinical samples linked to longitudinal clinical information in a manner that is responsive to our DDRCC investigators, requires a high level of clinical expertise in accurately phenotyping the patient subjects and a high level of stringent oversight in collecting clinical samples. For this reason, organization of tissue procurement at this institution has moved away from a single monolithic institutional unit attempting to collect a broad array of clinical samples from patients with many different diseases. Instead, tissue procurement is being conducted by smaller disease focused units, such as the DDRCC sponsored facility, that are linked to each other by a common biomedical informatics platforms (Tissue Suite and ClinPortal) developed and maintained by the CTSA-sponsored Center for Biomedical Informatics. Furthermore, the data output from two of the Research Core Facilities, the Functional Genomics Core and the Proteomics Core are in the process of being uploaded to databases (Profile DB) maintained by the ICTS Center for Biomedical Informatics.