ADMINISTRATIVE CORE AND ENRICHMENT PROGRAM

行政核心和强化计划

• 批准号: 7767531
• 负责人: Nicholas O. Davidson
• 金额: $ 35.57万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7767531
• 关键词: Center for Translational Science Activities; Clinical; Clinical and Translational Science Awards; Collection; Core Facility; Data; Databases; Digestive System Disorders; Discipline; Disease; Extramural Activities; Faculty; Functional disorder; Funding; Gastrointestinal Diseases; Gastrointestinal tract structure; Individual; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Institutes; Institution; Intestines; Investigation; Link; Liver; Maintenance; Medical; Mission; Output; Patients; Phenotype; Physicians; Postdoctoral Fellow; Process; Proteomics; Research; Research Personnel; Research Support; Resources; Sampling; Science; Services; System; Tissue Procurements; Tissues; Training; Translational Research; Universities; Washington; biomedical informatics; cost; functional genomics; graduate student; innovation; interest; member; profession allied to medicine; programs; success

The Washington University DDRCC is integrated with the NIH's Clinical Translational Science Award (CTSA) sponsored Washington University Institute of Clinical Translational Sciences (ICTS), primarily through the Clinical Component ofthe DDRCC and the ICTS Centerfor Biomedical Informatics. The DDRCC Clinical Component is primarily focused on providing investigators with access to clinical samples for digestive diseases related research. The collection and maintenance of clinical samples linked to longitudinal clinical information in a manner that is responsive to our DDRCC investigators, requires a high level of clinical expertise in accurately phenotyping the patient subjects and a high level of stringent oversight in collecting clinical samples. For this reason, organization of tissue procurement at this institution has moved away from a single monolithic institutional unit attempting to collect a broad array of clinical samples from patients with many different diseases. Instead, tissue procurement is being conducted by smaller disease focused units, such as the DDRCC sponsored facility, that are linked to each other by a common biomedical informatics platforms (Tissue Suite and ClinPortal) developed and maintained by the CTSA-sponsored Center for Biomedical Informatics. Furthermore, the data output from two of the Research Core Facilities, the Functional Genomics Core and the Proteomics Core are in the process of being uploaded to databases (Profile DB) maintained by the ICTS Center for Biomedical Informatics.

华盛顿大学DDRCC与NIH的临床翻译科学奖整合在一起 (CTSA)赞助华盛顿大学临床转化科学研究所(ICTS)，主要通过 DDRCC和ICTS生物医学信息学中心的临床部分。DDRCC临床 组件主要专注于为研究人员提供访问临床样本以进行消化的功能 疾病相关研究。与纵向临床相联系的临床样本的收集和维护 以响应我们的DDRCC调查人员的方式提供信息，需要高水平的临床 在准确地对患者样本进行表型鉴定方面的专业知识和在收集过程中的高度严格监督 临床样本。由于这个原因，该机构组织组织的组织采购已不再是 单一的整体式机构单位试图从患者身上收集广泛的临床样本 许多不同的疾病。取而代之的是，组织采购是由较小的专注于疾病的单位进行的， 例如DDRCC赞助的设施，它们通过共同的生物医学信息学相互链接 由CTSA赞助的中心开发和维护的平台(组织套件和ClinPortal) 生物医学信息学。此外，来自两个研究核心设施的数据输出，功能 基因组学核心和蛋白质组学核心正在上传到数据库中(配置文件数据库) 由ICTS生物医学信息学中心维护。