REGULATORY FACTORS IN THE GI TRACT

胃肠道的调节因素

• 批准号: 7846282
• 负责人: Nicholas O. Davidson
• 金额: $ 5.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7846282
• 关键词: REGULATORY; FACTORS; GI; TRACT

DESCRIPTION (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, focusing on regulatory factors in the GI tract. We believe that by gaining a fundamental understanding of the regulation of GI-processes, we will be able to more rationally prevent and treat GI diseases, including peptic ulcer, inflammatory bowel disease and acute and chronic liver diseases. Our philosophy is that the most effective way to develop new opportunities in digestive diseases related research is to invest in motivated individuals, especially at early stages of their careers. Consequently, the Washington University DDRCC focuses on mentoring and training students, residents, fellows and junior faculty with the goal of fostering new independent investigators in digestive diseases-related research. This center has excelled in developing young independent researchers though our Pilot/Feasibility Program. Our success can also be measured by the fact that both total extramural and NIDDK digestive diseases-related research base has more than doubled since the center's inception in 2000. The programmatic themes of the Digestive Diseases Research Core Center reflect its outstanding research base and are: 1.) Host-microbial interactions, inflammation and mucosal immunity; 2.) Gut development, differentiation and epithelial renewal; 3.) Nutrient transport, metabolism and signaling; 4.) Hepatobiliary metabolism, injury-repair. Washington University DDRCC investigators have been at the forefront in each of these programmatic themes. Partnership between a junior DDRCC investigator and clinical gastroenterologist has led to a novel paradigm in the treatment of inflammatory bowel disease. DDRCC investigators have pioneered the use of DNA microarray analyses of laboratory and clinical human samples to identify novel biomarkers and mediators in each of the four programmatic themes. These successes have in turn prompted us to propose to expand the Research Core services, including gnotobiotics, laser capture microdissection, DNA microarray, proteomics and bioinformatics. The goals of this DDRCC are to continue to promote and enhance interdisciplinary digestive disease research through its four research core facilities (Murine Models, Morphology, Functional Genomics and Proteomics).

描述（由申请人提供）： 该应用程序是为了持续支持华盛顿大学圣路易斯的消化系统疾病研究核心中心（DDRCC），重点关注胃肠道的监管因素。我们认为，通过对GI-Processes的调节有基本的了解，我们将能够在理性上预防和治疗胃肠道疾病，包括消化性溃疡，炎症性肠病以及急性和慢性肝脏疾病。我们的理念是，在消化疾病相关研究中开发新机会的最有效方法是投资于积极进取的人，尤其是在其职业生涯的早期阶段。因此，华盛顿大学DDRCC专注于指导和培训学生，居民，研究员和初级教师，目的是培养与消化疾病相关的研究的新独立研究者。通过我们的飞行员/可行性计划，该中心在发展年轻的独立研究人员方面表现出色。我们的成功也可以通过以下事实来衡量，即自2000年中心成立以来，与之相关的总壁外和NIDDK消化疾病相关的研究基础已增加了一倍以上。消化疾病研究核心中心的程序化主题反映了其出色的研究基础，并且是其出色的研究基础，并且是：1。）宿主 - 菌丝相互作用，炎症，炎症和粘膜免疫力； 2.）肠道发展，分化和上皮更新； 3.）营养转运，代谢和信号传导； 4.）肝胆代谢，损伤修复。华盛顿大学DDRCC调查人员在每个程序主题中都处于最前沿。初级DDRCC调查员与临床胃肠病学家之间的伙伴关系导致了治疗炎症性肠病的新型范式。 DDRCC研究人员开创了对实验室和临床人类样品的DNA微阵列分析的使用，以鉴定四个程序性主题中的每个主题中的每个新型生物标志物和介体。这些成功反过来促使我们建议扩大研究核心服务，包括gnotobiotics，激光捕获微分解，DNA微阵列，蛋白质组学和生物信息学。该DDRCC的目标是通过其四个研究核心设施（鼠模型，形态，功能基因组学和蛋白质组学）继续促进和增强跨学科的消化疾病研究。