Regulatory Factors in the GI Tract

胃肠道的调节因素

• 批准号: 8385588
• 负责人: Nicholas O. Davidson
• 金额: $ 105.98万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8385588
• 关键词: Address; Archives; Biological Process; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Core Facility; Data; Digestive System Disorders; Discipline; Disease; Extramural Activities; Faculty; Functional disorder; Funding; Gastrointestinal Diseases; Gastrointestinal tract structure; Gnotobiotic; Individual; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Intestines; Investigation; Link; Liver; Longitudinal Studies; Medical Students; Mission; Modeling; Morphology; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Pathogenesis; Patients; Physicians; Play; Postdoctoral Fellow; Process; Proteomics; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Science; Services; System; Time; Tissue Procurements; Training; Translational Research; Universities; Washington; base; biomedical informatics; career development; cost; cost effective; functional genomics; graduate student; innovation; interest; member; profession allied to medicine; programs; success

DESCRIPTION, OVERALL (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, which is the central institutional resource for investigators interested in the regulatory mechanisms and pathophysiology of the gastrointestinal tract and liver. The central focus of investigation is on inflammatory bowel diseases and its complications. However, we take a broad view of relevant research and will continue to support research on basic biological processes relevant to inflammatory bowel diseases, even if the systems being studied are not immediately applicable to inflammatory bowel diseases. The DDRCC supports an outstanding Research Base consisting of 62 Investigators in 10 departments with research grants totaling $17.5 million dollars (47% NIDDK funding). The DDRCC sustains its strong Research Base by actively supporting career development of new investigators through its Pilot/Feasibility Program. Nine former and four current Pilot/Feasibility awardees currently contribute to the Research Base. Four research core facilities (Murine Models/Gnotobiotic Core, Morphology Core, Functional Genomics Core and Proteomics Core) play a central role in promoting collaboration and synergy between individuals. They pool resources to provide services and expertise that would be cost and time- prohibitive to develop de novo, and maintain. To facilitate the conduct of clinical and translational research in inflammatory bowel diseases, the Clinical Component of the DDRCC consists of a Tissue Procurement Facility archives clinical samples linked to longitudinal clinical information ( >1,100 patients with inflammatory bowel diseases recruited in three years) and promotes new collaborative and synergistic interactions between basic researchers and clinicians. The DDRCC Clinical Component and Research Core facilities are integrated within the framework of the Clinical Translational Science Award - sponsored biomedical informatics infrastructure. By collecting clinical samples and linking them to integrated clinical information collected in focused longitudinal studies and research data generated from these samples by the DDRCC Research Core Facilities, the DDRCC is building a comprehensive multidimensional discovery platform from which investigators can launch further hypothesis-driven studies on inflammatory bowel disease pathogenesis.

描述，总体（由申请人提供）： 该应用是为了持续支持华盛顿大学圣路易斯的消化疾病研究核心中心（DDRCC），这是对胃肠道和肝脏的调节机制和病理生理学感兴趣的研究人员的中央机构资源。调查的主要重点是炎症性肠病及其并发症。但是，我们对相关研究的广泛看法，并将继续支持对与炎症性肠道疾病相关的基本生物学过程的研究，即使所研究的系统不立即适用于炎症性肠道疾病。 DDRCC支持了一个杰出的研究基础，该研究基础由62位研究人员组成，其中10个部门的研究赠款总计1750万美元（NIDDK资金为47％）。 DDRCC通过通过其试点/可行性计划积极支持新研究人员的职业发展来维持其强大的研究基础。目前有9名以前和四名前进/可行性获奖者为研究基础做出了贡献。四个研究核心设施（鼠模型/gnotobiotic核心，形态核心，功能基因组学核心和蛋白质组学核心）在促进个人之间的协作和协同作用方面起着核心作用。他们集中资源以提供服务和专业知识，这些服务和专业知识将使从头发展和维护，这将是成本和时间的。为了促进炎症性肠病中的临床和转化研究的进行，DDRCC的临床成分由组织采购设施组成的临床样本与纵向临床信息相关的临床样本（> 1,100例炎症性肠道疾病患者，三年中招募了炎症性肠道疾病），并促进了新的协作和Synergistic和Synergistic Internergistic互动和基础研究员之间的互动。 DDRCC临床组件和研究核心设施都集成到临床转化科学奖的框架内 - 赞助的生物医学信息学基础设施。通过收集临床样本并将其与DDRCC研究核心设施从这些样本产生的重点纵向研究和研究数据中收集的综合临床信息联系起来，DDRCC正在建立一个全面的多维发现平台，研究人员可以从中启动对炎症性肠病病原体的进一步假设驱动的研究。