IMAGE GUIDED THERAPY CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请人提供)：我们请求继续为布里格姆妇女医院的影像引导治疗国家生物医学资源中心(NCIGT)提供资金。该中心为影像指导治疗领域的转化性研究提供了独特的集中式基础设施。这项多学科计划包括临床研究人员、生物医学工程师和基础科学家，促进和推进IGT方法和相关的创新临床应用。我们将在六个离散的TRD核心项目中开发和提供与临床相关的新技术：1)计算核心；2)成像核心；3)图像引导核心；4)神经外科核心；5)前列腺核心和6)聚焦超声治疗核心。这些关键的研究计划代表了该资源的技术和临床基础设施。预计它们将对未来的几种IGT方法和临床应用产生重大影响。我们将与7个独立资助的合作(DBP)联合起来，解决IGT的各种基本技术或临床方面，我们的贡献将对临床产生重大影响。我们的目标是将当前成像领域的进展(如分子成像、功能成像和新陈代谢成像)与先进疗法(如MRI引导的聚焦超声消融或靶向药物输送、内窥镜手术或机器人)相结合，以实现侵入性更小、更安全和更有效的治疗方案。所有IGT开发和应用程序都将在我们的网站或我们的合作者处进行测试和验证，或者直接作为服务分发给不断增长的IGT社区。我们的首要目标是继续成为领先的国家中心，通过服务、培训和传播这一资源正在开发的新技术和方法，有效地覆盖广泛的人群。 与公共健康相关：这一应用的主要推动力是推进和宣传新的影像引导治疗技术，有效地产生加强的多学科研究努力和与尖端技术发展相称的基础设施。我们还致力于将我们的技术广泛提供给广大临床医生。我们的使命是开发和实施新颖、创新的技术，以减少手术和干预的侵入性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): We are requesting continuation of funds for the National Biomedical Resource Center in Image-guided Therapy (NCIGT) at the Brigham & Women's Hospital. The Center provides a unique, centralized infrastructure for translational research in the area of image-guided therapy. The multidisciplinary program involves clinical investigators, biomedical engineers, and basic scientists in promoting and advancing IGT methods and related innovative clinical applications. We will develop and make available new, clinically relevant technologies in six discrete TRD Core Projects: 1) Computational Core; 2) Imaging Core; 3) Image- Guidance Core; 4) Neurosurgery Core; 5) Prostate Core and 6) Focused Ultrasound Therapy Core. These key research initiatives represent the technical and clinical infrastructure of the Resource. They are anticipated to have significant effect on several future IGT methods and clinical applications. We will combine forces with 7 independently funded Collaborations (DBPs) that address various essential technical or clinical aspects of IGT and our contribution will have significant clinical impact. Our goal is to combine current advances in the field of imaging (like Molecular Imaging, Functional and Metabolic Imaging) with advanced therapies (like MRI-guided Focused Ultrasound ablation or targeted drug delivery, endoscopic surgery or robotics) to achieve less invasive, safer and more effective therapeutic options. All IGT developments and applications will be tested and validated either on our site or at our collaborators, or distributed directly as a service to the growing IGT community. Our overarching goal is to continue being the leading National Center that reaching effectively across a broad range of constituencies through service, training and dissemination of the novel technologies and methods under development in this Resource. PUBLIC HEALTH RELEVANCE: The overarching impetus for this application is to advance and propagate novel image-guided therapy technologies, effectively producing strengthened multidisciplinary research efforts and an infrastructure commensurate with sophisticated technology development. We are also committed to making our technology broadly available to a large community of clinician. Our mission is to develop and implement novel, innovative technologies to decrease the invasiveness of surgeries and interventions.