MR GUIDED THERAPY

先生引导治疗

• 批准号: 7960869
• 负责人: Ferenc A Jolesz
• 金额: $ 5.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960869
• 关键词: Accounting; Address; Arts; Biopsy; Brachytherapy; Brain; Brain Neoplasms; Clinical Treatment; Complement; Computer Retrieval of Information on Scientific Projects Database; Computer Systems; Computer software; Computers; Computing Methodologies; Data; Devices; Diffusion Magnetic Resonance Imaging; Doctor of Philosophy; Electronics; Ensure; Environment; Focused Ultrasound Therapy; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Image; Imagery; Institution; Intervention; Libraries; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Manuals; Medical; Methods; Monitor; Motion; Neurosurgical Procedures; Operative Surgical Procedures; Patients; Phase; Physicians; Procedures; Prostate; Prostatic Neoplasms; Publishing; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Robotics; Scanning; Science; Side; Software Design; Source; System; Techniques; Technology; Testing; Thermal Ablation Therapy; Three-Dimensional Image; Translating; Ultrasonography; United States National Institutes of Health; Work; base; clinical application; cranium; data acquisition; design; design and construction; flexibility; image guided therapy; image processing; imaging modality; improved; infrastructure development; neurosurgery; non-invasive system; novel; programs; robotic device; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P01-CA67165 Program Project, Program Director Ferenc A. Jolesz MD IMAGE-GUIDED THERAPY Project Start: 30-SEP-1995 Project End: 30-APR-2012 Program Summary The long-term objective of the application under consideration, a competing renewal of our Program Project in MR-guided Therapy, is to provide the scientific, medical, and technical infrastructure for the development of interventional and intraoperative MRI for the treatment of brain and prostate cancer. This Program Project combines several technological advances related to the use of high field MRI with an advanced imaging platform. In parallel, this proposal addresses issues related to limited access to the patient in the closed bore magnet. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced 3Tesla imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new application environment. To this end, we will undertake the following research initiatives: Project 1: Develop computational methods that account for anatomical changes during neurosurgical intervention and optimize the frequency of serial imaging ; Project 2: Build an image-guided and controlled therapy delivery system for the non-invasive destruction of prostate cancer with MRI-controlled focused ultrasound; Project 3: Provide image-control for manipulators and robotic devices that enhances the manual capacity of physicians and facilitates procedures in a closed bore magnet; Project 4: Develop novel imaging platforms and methods for enhanced parallel MRI data acquisition applicable to image-guidance; and Project 5: Create an integrated image-based system to allow MR-guided targeted interventions for the treatment of prostate cancer. These five projects will work synergistically to not only develop better imaging methods for defining the cancers, but will also work to facilitate the improved, targeted treatment of brain tumors and prostate cancer. This proposal combines several technological advances related to the use of high field MRI for the image guided treatment of brain and prostate cancer. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced high field MRI imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new clinical application environment. Projects Overview Project 1 - Integrated Intraoperative Guidance for Neurosurgery - Alexandra J Golby MD & Neculai Archip PhD Project 2 - MR Guided Focused Ultrasound - Nathan J McDannold PhD & Gregory Clement PhD Project 3 - Image-Based Navigation for Interventional Robotic Devices Nobuhiko Hata PhD Project 4 - Enhanced Parallel MRI Data Acquisition - Gary P Zientara PhD & Lawrence P Panych PhD Project 5 - MRI Guided Interventions in the Prostate - Clare M Tempany MD Benefits to the NCIGT The main objective of the P01 Project 1 is to build a system to improve intraoperative visualization, navigation and monitoring for image-guided neurosurgery. This Project will serve as a testbed for the basic image-guided Neurosurgery technology that is developed in the U41 Image-Guide Brain Tumor Surgery Core. An objective of the P01 Project 1 is specifically to create an augmented reality visualization of the intraoperative configuration of the patient's brain merged with high resolution preoperative imaging data, including honing the science to improve intraoperative navigation, targeting and visualization, again implementation issues. This Project and Project 3 necessarily will make direct use of the techniques and facilites developed under the U41 Computational Core. Project 3 has the main objective to develop accurate and robust methods for tracking the motion of interventional devices during MRI-guided procedures, an effort complementing the aims of the U41. The main objective of the P01 Project 4 is implementation-focused research for the AMIGO suite, to translate the latest 3D dynamic imaging technical advances - specifically published techniques in Parallel MRI and reduced field-of-view methods - into practical functions on the 3T 16-channel MRI scanner that will be part of our AMIGO suite. This Project is highly complementary to the U41 Imaging Core's goal of producing Parallel MRI libraries, and will become a testbed for the products of the U41 Imaging Core. The main objective of the P01 Project 2 is to both use intracavitary ultrasound phased arrays to effectively coagulate prostate tumors, and use through-the-skull FUS technology to ablate brain tumors. This Project again will serve as a testbed for the technology developed in the U41 Focused Ultrasound Core, which is devoted to designing and building phased array systems for FUS. The main objective of the P01 Project 5 is focused on the implementation aspects of the prostate IGT application, to adapt, for a 3T scanner, and use MR-guided prostate brachytherapy and biopsy computer software originally developed for the 0.5T scanner. This Project will benefit the U41 MRT Core since it will provide a special application case supporting the aim of the U41 MRT Core, which is to design and perform completely new IGT procedures for MR-guided neuro-surgery, MR-guided prostate interventions and MR-guided thermal ablations. Benefits to the Project The main objective of the U41 Image-Guide Brain Tumor Surgery Core is to develop the infrastructure required to translate basic technological advances from other parts of the effort to the clinical treatment of patients with brain tumors (includes: high-resolution functional MRI (fMRI), diffusion tensor imaging (DTI), and intraoperative electrophysiologic testing (ECS)). This has a tremendous benefit to P01 Project 1 since this Core is focused on developing the basic technology to enable the Neurosurgical procedures aimed to be accomplished in the P01 Project 1. The main objective of the U41 Computational Core is to develop general technology to ensure accuracy in determining coordinate systems, coordinate transformations, and device coordinates used in MRT/Slicer projects, develop general user interface software, computer systems specialized as MR scanner adjuncts for IGT, and HPC versions of state-of-the-art 3D image processing software. This Core will mainly provide the basic computer and AMIGO table-side technology for P01 Project 3, which will implement robotics applications for IGT. Also, The U41 Computational Core will provide programming and up-to-date software design expertise to the P01 Project 4. The main objective of the U41 Imaging Core project is to develop novel fast and efficient imaging methods, such as non-Fourier RF encoding, line-scan imaging and parallel imaging, and make them available as a resource for enhancing the full range of MRI-guided therapy applications. A major product of the U41 Imaging Core is the DARTS realtime data acquisition system, which will become an integral part of the fast imaging implementation aimed for in the P01 Project 4. Again, the U41 research provides the basic technology to enable the implementation and application research in the P01. The main objective of the Focused Ultrasound Core proposal is to take an advantage of two dimensional ultrasound phased arrays for image guided thermal ablation, including designing ultrasound phased array applicators that will provide electronic beam steering, constructing the ultrasound phased array applicators to test the design, and testing to verify the design and construction. This research will provide the key ingredients for the FUS application-oriented Project 2 of the P01.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 P01-CA67165计划项目，程序总监Ferenc A. Jolesz MD 图像引导的治疗 项目开始：1995年9月30日 项目结束：2012年4月30日 程序摘要 该应用程序的长期目标是对MR引导治疗计划项目的竞争续订，是为开发介入和术中MRI的发展提供科学，医学和技术基础设施，用于治疗脑和前列腺癌。该计划项目结合了与高场MRI使用与高级成像平台有关的几种技术进步。同时，该提案解决了与封闭孔中对患者访问有限有关的问题。目的是将大多数程序（开放手术，热消融）移至高级3TESLA成像平台，以实现更快，更灵活的图像获取，从而为这些程序提供了改进的定位，靶向，监测，监测和治疗控制，以适应这个新的应用程序环境。为此，我们将执行以下研究计划： 项目1：开发计算方法，以说明神经外科干预期间的解剖变化并优化串行成像的频率； 项目2：建立一个图像引导和受控的治疗输送系统，以使用MRI控制的集中超声检查前列腺癌的非侵入性破坏； 项目3：为操纵器和机器人设备提供图像对照，以增强医生的手动能力并促进封闭孔中的程序； 项目4：开发新颖的成像平台和方法，以增强适用于图像指导的平行MRI数据采集；和 项目5：创建一个基于图像的集成系统，以允许MR引导的靶向干预措施治疗前列腺癌。 这五个项目将协同起作用，不仅开发出更好的成像方法来定义癌症，而且还可以促进改善，有针对性的脑肿瘤和前列腺癌的治疗方法。该提案结合了与使用高场MRI进行图像指导治疗大脑和前列腺癌的几种技术进步。目的是将大多数程序（开放手术，热消融）移至先进的高场MRI成像平台，以实现更快，更灵活的图像获取，从而为这些程序提供了改进的定位，靶向，监测和治疗控制，以适应这个新的临床应用环境。 项目概述 项目1-神经外科综合术中指南-Alexandra J Golby MD和Neculai Archip PhD 项目2 -MR指导专注超声 - Nathan J McDannold PhD和Gregory Clement博士 项目3-基于图像的导航，用于介入的机器人设备Nobuhiko Hata博士 项目4-增强的并行MRI数据获取-Gary P Zientara PhD和Lawrence P Panych Phd 项目5-前列腺中MRI指导干预措施-Clare M Tempany MD ncigt的好处 P01项目1的主要目的是建立一个系统，以改善术中可视化，导航和监测图像引导的神经外科手术。该项目将作为在U41图像指南脑肿瘤手术核心中开发的基本图像引导神经外科技术的测试台。 P01项目1的一个目的是专门为对患者大脑进行术中大脑的术中配置与高分辨率术前成像数据合并的增强现实可视化，包括磨练科学以改善术中导航，靶向定位和可视化，再次实施问题。该项目和项目3必须直接使用U41计算核心开发的技术和设施。项目3的主要目标是开发准确，可靠的方法，用于在MRI引导程序中跟踪介入设备的运动，这是对U41目标的补充。 P01项目4的主要目的是针对Amigo Suite的实施研究，以翻译最新的3D动态成像技术进步 - 专门以并行MRI的发行技术，并减少了视野方法 - 在3T 16-CHANNEL MRI SCANNER上的实际功能，这将是我们Amigo Suite的一部分。该项目与U41 Imaging Core生成并行MRI库的目标高度互补，并将成为U41成像核心产品的测试床。 P01项目2的主要目的是使用腔内超声阶段阵列有效地凝结了前列腺肿瘤，并使用整个乳突技术来消除脑肿瘤。该项目将再次充当U41专注超声核心中开发的技术的测试台，该技术致力于设计和构建用于FUS的阶梯阵列系统。 P01项目5的主要目标集中于前列腺IGT应用程序的实施方面，以适应3T扫描仪，并使用最初为0.5T扫描仪开发的MR引导的前列腺近距离治疗和活检计算机软件。该项目将使U41 MRT核心受益，因为它将提供一个特殊的应用程序案例，以支持U41 MRT核心的目的，该核心是为MR引导神经手术，MR引导的前列腺干预和MR引导的热水体设计和执行全新的IGT程序。 对项目的好处 U41图像指南脑肿瘤手术核心的主要目的是开发将基本技术进步从其他部位转化为脑瘤患者的临床治疗所需的基础设施（包括：高分辨率功能性MRI（FMRI），扩散张量成像（DTI）（DTI）（DTI）（DTI）和内部电流测试（授予）。这对P01项目1具有巨大的好处，因为该核心专注于开发基本技术，以使旨在在P01项目1中完成的神经外科程序。 U41计算核心的主要目的是开发通用技术，以确保MRT/Slicer项目中使用的坐标系统，坐标转换和设备坐标的准确性，开发通用用户界面软件，专门为IGT的MR Scanner辅助功能的计算机系统以及Sant-the-Art-the-Art 3D图像处理软件的HPC版本。 该核心将主要为P01 Project 3提供基本的计算机和Amigo桌面技术，该技术将实施IGT的机器人技术应用程序。此外，U41计算核心将为P01项目4提供编程和最新的软件设计专业知识。 U41成像核心项目的主要目的是开发新型快速有效的成像方法，例如非焦室编码，线扫描成像和平行成像，并使其作为增强MRI辅助治疗应用的资源。 U41成像核心的主要产品是DARTS实时数据采集系统，该系统将成为P01 Project 4旨在实施快速成像实施的组成部分。同样，U41研究提供了基本技术，以实现P01中的实施和应用研究。 专注的超声核心提案的主要目的是利用图像引导的热消融的二维超声阶段阵列，包括设计超声段的施用器，这些量度将提供电子光束转向，从而构建超声型置换阵列涂抹器，以测试设计和测试以验证设计和构建的设计。这项研究将为P01的面向应用程序的项目2提供关键成分。