MR GUIDED THERAPY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 P01-CA67165计划项目，计划总监Ferenc A.Jolesz MD 影像引导疗法 项目开始时间：4/1/2007 计划摘要 正在考虑中的申请是我们MR引导治疗计划项目的竞争性更新，其长期目标是为开发用于脑和前列腺癌治疗的介入性和术中MRI提供科学、医学和技术基础设施。该计划项目结合了几项与使用高场磁共振相关的技术进步和先进的成像平台。同时，这项提案还解决了与在闭孔磁铁中接触患者的限制有关的问题。其目标是将大多数程序(开放手术、热消融)转移到先进的3Tesla成像平台，以实现更快、更灵活的图像采集，从而为那些可以适应这种新应用环境的程序提供更好的定位、靶向、监测和治疗控制。为此，我们将开展以下研究工作： 项目1：开发计算方法，解释神经外科干预过程中的解剖变化，并优化序列成像的频率； 项目2：利用MRI控制的聚焦超声建立一个图像引导和控制的前列腺癌非侵入性治疗输送系统； 项目3：为机械手和机器人设备提供图像控制，以增强医生的手动能力，并促进闭孔磁体中的程序； 项目4：开发新的成像平台和方法，以增强适用于成像制导的并行磁共振数据采集；以及 项目5：创建一个集成的基于图像的系统，以允许在MR引导下对前列腺癌进行有针对性的干预。 这五个项目将协同工作，不仅开发出更好的定义癌症的成像方法，而且还将努力促进改进的、有针对性的脑瘤和前列腺癌治疗。这项建议结合了几项与使用高场磁共振图像引导治疗脑癌和前列腺癌相关的技术进步。其目标是将大多数手术(开放手术、热消融)转移到先进的高场磁共振成像平台，以实现更快、更灵活的图像采集，从而为那些能够适应这种新的临床应用环境的手术提供更好的定位、靶向、监测和治疗控制。 项目概述 项目1-神经外科综合术中指导-Alexandra J Golby医学博士和Neculai ArChip博士 项目2-MR引导的聚焦超声-Nathan J McDannold博士和Gregory Clement博士 项目3-基于图像的介入性机器人设备导航 项目4-增强的并行磁共振数据采集-Gary P Zientara博士和Lawrence P Panych博士 项目5-MRI引导介入治疗前列腺癌-Clare M Tempany MD

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P01-CA67165 Program Project, Program Director Ferenc A. Jolesz MD IMAGE-GUIDED THERAPY Project Start: 4/1/2007 Program Summary The long-term objective of the application under consideration, a competing renewal of our Program Project in MR-guided Therapy, is to provide the scientific, medical, and technical infrastructure for the development of interventional and intraoperative MRI for the treatment of brain and prostate cancer. This Program Project combines several technological advances related to the use of high field MRI with an advanced imaging platform. In parallel, this proposal addresses issues related to limited access to the patient in the closed bore magnet. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced 3Tesla imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new application environment. To this end, we will undertake the following research initiatives: Project 1: Develop computational methods that account for anatomical changes during neurosurgical intervention and optimize the frequency of serial imaging ; Project 2: Build an image-guided and controlled therapy delivery system for the non-invasive destruction of prostate cancer with MRI-controlled focused ultrasound; Project 3: Provide image-control for manipulators and robotic devices that enhances the manual capacity of physicians and facilitates procedures in a closed bore magnet; Project 4: Develop novel imaging platforms and methods for enhanced parallel MRI data acquisition applicable to image-guidance; and Project 5: Create an integrated image-based system to allow MR-guided targeted interventions for the treatment of prostate cancer. These five projects will work synergistically to not only develop better imaging methods for defining the cancers, but will also work to facilitate the improved, targeted treatment of brain tumors and prostate cancer. This proposal combines several technological advances related to the use of high field MRI for the image guided treatment of brain and prostate cancer. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced high field MRI imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new clinical application environment. Projects Overview Project 1 - Integrated Intraoperative Guidance for Neurosurgery - Alexandra J Golby MD & Neculai Archip PhD Project 2 - MR Guided Focused Ultrasound - Nathan J McDannold PhD & Gregory Clement PhD Project 3 - Image-Based Navigation for Interventional Robotic Devices Nobuhiko Hata PhD Project 4 - Enhanced Parallel MRI Data Acquisition - Gary P Zientara PhD & Lawrence P Panych PhD Project 5 - MRI Guided Interventions in the Prostate - Clare M Tempany MD