MR GUIDED THERAPY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 P01-CA 67165程序项目，程序总监Ferenc A. Jolesz MD 图像引导治疗 项目开始日期：2007年4月1日 节目概要 正在考虑的申请的长期目标是为开发用于治疗脑癌和前列腺癌的介入性和术中MRI提供科学、医疗和技术基础设施。该计划项目结合了与使用高场MRI相关的几项技术进步和先进的成像平台。同时，该提案解决了与闭孔磁体中患者接触受限相关的问题。其目标是将大多数手术（开放手术、热消融）转移到先进的3 T成像平台，以实现更快、更灵活的图像采集，从而为那些可以适应新应用环境的手术提供更好的定位、靶向、监测和治疗控制。为此，我们将开展以下研究活动： 项目一：开发计算方法，解释神经外科干预期间的解剖变化，并优化序列成像的频率; 项目二：建立一个图像引导和控制的治疗系统，用于MRI控制的聚焦超声无创性破坏前列腺癌; 项目三：为机械手和机器人设备提供图像控制，提高医生的手动能力，并促进闭孔磁体中的程序; 项目4：开发适用于图像引导的增强并行MRI数据采集的新型成像平台和方法;以及 项目5：创建一个基于图像的集成系统，以允许MR引导的靶向干预治疗前列腺癌。 这五个项目将协同工作，不仅开发更好的成像方法来定义癌症，而且还将致力于促进改善脑肿瘤和前列腺癌的靶向治疗。该提案结合了与使用高场MRI进行脑癌和前列腺癌的图像引导治疗相关的几项技术进步。其目标是将大多数手术（开放手术、热消融）转移到先进的高场MRI成像平台，以实现更快、更灵活的图像采集，进而为这些手术提供更好的定位、靶向、监测和治疗控制，以适应这种新的临床应用环境。 项目概览 项目1 -神经外科的综合术中指导- Alexandra J Golby MD & Neculai Archip PhD 项目2 - MR引导聚焦超声- Nathan J McDannold博士和Gregory Clement博士 项目3 -介入机器人设备的基于图像的导航 秦信彦博士 项目4 -增强型并行MRI数据采集-加里P Zientara博士和劳伦斯P Panych博士 项目5 -前列腺MRI引导介入-克莱尔M Tempany医学博士

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P01-CA67165 Program Project, Program Director Ferenc A. Jolesz MD IMAGE-GUIDED THERAPY Project Start: 4/1/2007 Program Summary The long-term objective of the application under consideration, a competing renewal of our Program Project in MR-guided Therapy, is to provide the scientific, medical, and technical infrastructure for the development of interventional and intraoperative MRI for the treatment of brain and prostate cancer. This Program Project combines several technological advances related to the use of high field MRI with an advanced imaging platform. In parallel, this proposal addresses issues related to limited access to the patient in the closed bore magnet. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced 3Tesla imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new application environment. To this end, we will undertake the following research initiatives: Project 1: Develop computational methods that account for anatomical changes during neurosurgical intervention and optimize the frequency of serial imaging ; Project 2: Build an image-guided and controlled therapy delivery system for the non-invasive destruction of prostate cancer with MRI-controlled focused ultrasound; Project 3: Provide image-control for manipulators and robotic devices that enhances the manual capacity of physicians and facilitates procedures in a closed bore magnet; Project 4: Develop novel imaging platforms and methods for enhanced parallel MRI data acquisition applicable to image-guidance; and Project 5: Create an integrated image-based system to allow MR-guided targeted interventions for the treatment of prostate cancer. These five projects will work synergistically to not only develop better imaging methods for defining the cancers, but will also work to facilitate the improved, targeted treatment of brain tumors and prostate cancer. This proposal combines several technological advances related to the use of high field MRI for the image guided treatment of brain and prostate cancer. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced high field MRI imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new clinical application environment. Projects Overview Project 1 - Integrated Intraoperative Guidance for Neurosurgery - Alexandra J Golby MD & Neculai Archip PhD Project 2 - MR Guided Focused Ultrasound - Nathan J McDannold PhD & Gregory Clement PhD Project 3 - Image-Based Navigation for Interventional Robotic Devices Nobuhiko Hata PhD Project 4 - Enhanced Parallel MRI Data Acquisition - Gary P Zientara PhD & Lawrence P Panych PhD Project 5 - MRI Guided Interventions in the Prostate - Clare M Tempany MD