MORPHOMETRY DIFFERENTIATES FRAGILE X SYNDROME & CONTROL BOYS AGES 1-3

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究遗传疾病，如脆性X综合征（FXS），这是一种由单一基因突变引起的疾病，导致异常树突和突触修剪，以及健康个体 可能为研究基因、脑-行为关系提供有价值的信息。 具体目的：研究形态空间模式，区分FXS从控制在幼儿期。 研究方法：共对101名1至3岁的儿童进行了基于体素的形态测量学检查; 51名FXS男孩，32名典型发育（TD）男孩和18名特发性发育迟缓（DD）男孩。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies of genetic disorders such as fragile X syndrome (FXS) which is a disorder caused a single gene mutation resulting in abnormal dendritic and synaptic pruning, together with healthy individuals may provide valuable information to study gene, brain-behavior relationship. Specific Aims: To examine morphometric spatial patterns that differentiate between FXS from controls in early childhood. Methods: Voxel-based morphometry was examined in a total of 101 children of ages 1 to 3; 51 boys with FXS, 32 typically developing (TD) boys and 18 boys with idiopathic developmental delay (DD).