STRUCTURAL BRAIN DIFFERENCES BETWEEN AUTISTIC AND TYPICALLY-DEVELOPING SIBLINGS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 导言： 然而，自闭症儿童和发育正常的儿童之间的大脑形态差异已经被识别出来 不同的研究结果并不一致。一个潜在的原因是脑部形态的变化 多种遗传和环境因素对脑发育的影响。控制这些因素的策略是 比较自闭症不协调的兄弟姐妹的大脑结构。 具体目标： 用基于体素的形态计量学检查兄弟姐妹来评估脑形态与自闭症的关系 对自闭症不和谐。 方法： 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/(卢卡斯年度报告和 ISMRM 2011年摘要)

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction: Morphologic brain differences have been identified between children with autism and typically-developing children, though findings have been inconsistent across studies. One potential cause is the variability in brain morphology resulting from the influence of multiple genetic and environmental factors on brain development. A strategy to control for such factors is to compare brain structure between siblings discordant for autism. Specific Aim: To assess the relationship between brain morphology and autism using voxel-based morphometry to examine siblings discordant for autism. Methods: To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)