Project 3: Immunoassays for Human and Environmental Monitoring
Project 3: Immunoassays for Human and Environmental Monitoring
批准号:
7936569
负责人:
BRUCE D HAMMOCK
金额:
$22.24万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-04-15 至 2015-03-31
关键词:
AddressAgricultureAgrochemicalsAntibodiesAreaBacteriophagesBiological AssayBiological MarkersBiosensorCellsChemicalsCollaborationsDetectionDevelopmentDiamideDioxinsElectronicsEnvironmentEnvironmental ExposureEnvironmental MonitoringEnvironmental PollutionEthersExposure toFishesFlame RetardantsFurnitureGeneral PopulationGlucuronidesGoalsGovernmentHazardous SubstancesHealthHome environmentHumanImmunoassayImmunological DiagnosisIndividualIndustrial ProductIndustryInorganic SulfatesInsecticidesInstitutionInvertebratesLabelLaboratoriesLanthanoid Series ElementsMagnetismMeasurementMeasuresMethodsModelingOrganismParentsPermethrinPest ControlPhage DisplayPhasePolybrominated BiphenylsPolychlorinated BiphenylsPolymersReagentRefuse DisposalResearchResearch PersonnelResistanceSamplingSampling StudiesScientistSilicon DioxideSilverSiteSolidSourceSpeedSuperfundTechniquesTechnologyToxic effectTraining SupportTriclosanUnspecified or Sulfate Ion SulfatesValidationanalytical methodantimicrobialassay developmentbasecostdesigndetectordiphenylexposed human populationfipronilimprintimprovednanoparticlenew technologynovelparticlephenyl etherpollutantpreventsewage treatmenttetrabromobisphenol Atooltoxicanttriclocarban
中文摘要
为了了解环境暴露对人的影响以及由此产生的潜在健康影响,需要快速、准确地测量暴露的方法。免疫分析法是一种使用抗体作为检测器的简单而灵敏的测量方法。本项目制作、改进和使用免疫测定法来检测有可能广泛暴露的化学品
英文摘要
To understand the effect of environmental exposures on people and the resulting potential health effects, rapid, accurate methods to measure exposures are needed. An immunoassay is a simple and sensitive measurement method that uses antibodies as detectors. This project makes, improves and uses immunoassays for chemicals that have potential for widespread exposure and a
potential impact on human health with the goal preventing or minimizing exposures. Using concepts pioneered in this group, mimics of the compound are chemically or biologically synthesized. The mimics are used to raise antibodies that are specific for the environmental compound. The mimics and antibodies are formatted into assays that are analytically well characterized. The assays are then applied to various studies of human or environmental exposure. Among environmental contaminants to be addressed by this project are the insecticides, permethrin, fipronil and chlorantraniliprole. In addition to toxicity to non target organisms such as fish and aquatic invertebrates, these insecticides are used in agricultural settings, at home, as well as by pest
control operators. Exposure to the general population is likely. Assays are also proposed for the brominated flame retardants, polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A and, newly emerging environmental contaminants, the antimicrobial compounds triclosan and triclocarban. PBDEs appear in the environment through waste disposal of electronics and furniture while antimicrobial compounds are resistant to sewage treatment. To assess human exposure, assays to the human metabolites of these compounds are also proposed. Novel magneticluminescent labels for simultaneous measurement of multiple compounds will be developed to speed throughput. A technique called phage display will be use to make mimics of key assay reagents in order to make assays more selective.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics.
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批准号:10708436
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项目类别:
-
资助金额:$48.42万
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财政年份:2023
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负责人:BRUCE D HAMMOCK
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依托单位:
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
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批准号:10400036
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项目类别:
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资助金额:$75.68万
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财政年份:2019
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负责人:BRUCE D HAMMOCK
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依托单位:
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
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批准号:10615675
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项目类别:
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资助金额:$75.68万
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财政年份:2019
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负责人:BRUCE D HAMMOCK
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依托单位:
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
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批准号:10153794
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项目类别:
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资助金额:$73.76万
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财政年份:2019
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负责人:BRUCE D HAMMOCK
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依托单位:
Clinical Paths for Soluble Epoxide Hydrolase Inhibitors at Experimental Biology 2018
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批准号:9544621
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项目类别:
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资助金额:$1.5万
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财政年份:2018
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负责人:BRUCE D HAMMOCK
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依托单位:
Role of Epoxygenated Fatty Acids in Modulating Pain
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批准号:8446055
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项目类别:
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资助金额:$19.64万
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财政年份:2013
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负责人:BRUCE D HAMMOCK
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依托单位:
Role of Epoxygenated Fatty Acids in Modulating Pain
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批准号:8619587
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项目类别:
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资助金额:$16.36万
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财政年份:2013
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负责人:BRUCE D HAMMOCK
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依托单位:
Analytical Chemistry
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批准号:10204120
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项目类别:
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资助金额:$45.58万
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财政年份:2012
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负责人:BRUCE D HAMMOCK
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依托单位:
METHODS MONITOR TOXIC SUBSTAN AND/OR INDICATORS OF PRESENCE IN HUMANS&OTHER SPE
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批准号:8362756
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项目类别:
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资助金额:$7.02万
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财政年份:2011
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负责人:BRUCE D HAMMOCK
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依托单位:
EFFECT OF PHTHALATES ON PRIMATE PREGNANCY
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批准号:8357275
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项目类别:
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资助金额:$5.04万
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财政年份:2011
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负责人:BRUCE D HAMMOCK
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依托单位:
ID AND DEV OF BIOLOGICAL MARKERS OF HUMAN EXPOSURE TO THE INSECTICIDE PERMETHRI
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批准号:8362754
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项目类别:
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资助金额:$16.38万
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财政年份:2011
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负责人:BRUCE D HAMMOCK
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依托单位:
EFFECT OF BROMODICHLOROMETHANE ON PLACENTAL DEVELOPMENT
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批准号:8172527
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项目类别:
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资助金额:$7.6万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
EFFECT OF PHTHALATES ON PRIMATE PREGNANCY
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批准号:8172548
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项目类别:
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资助金额:$7.6万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
ID AND DEV OF BIOLOGICAL MARKERS OF HUMAN EXPOSURE TO THE INSECTICIDE PERMETHRI
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批准号:8171681
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项目类别:
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资助金额:$5.1万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
Project 4: Urinary Protein Biomarkers for Assessing the Potential Toxicity
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批准号:7936571
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项目类别:
-
资助金额:$14.82万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
Administrative Core
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批准号:7936578
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项目类别:
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资助金额:$14.29万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
Project 2: Development of Rapid, Miniaturized Biosensors
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批准号:7936568
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项目类别:
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资助金额:$17.3万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
Research Translation Core
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批准号:7936581
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项目类别:
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资助金额:$7.4万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
Project 6: Assessing Adverse Effects of Environmental Hazards on Reproductive
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批准号:7936574
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项目类别:
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资助金额:$14.82万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
Project 5: Development and Applications of Integrated in Vitro and Cell-Based
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批准号:7936573
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项目类别:
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资助金额:$54.15万
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财政年份:2010
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负责人:BRUCE D HAMMOCK
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依托单位:
海外基金