Impact of somatic versus dendritic inhibition on neuronal output

体细胞抑制与树突抑制对神经元输出的影响

• 批准号: nhmrc : 1069226
• 负责人: Prof Greg Stuart
• 金额: $ 69.86万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-somatic-versus-neuronal-output/455378
• 关键词: Impact; somatic; versus; dendritic; inhibition

The brain is made up of literally billions of neurons connected in complex networks. These neurons come in two primary flavors - excitatory and inhibitory - which work in balance. Too much excitation and the brain becomes epileptic, too much inhibitory and we go into a coma. This proposal focuses on the role of specific inhibitory cell types in regulating brain function, and has relevant to a range of neurological disorders from epilepsy, to schizophrenia to depression.

大脑由数十亿个神经元组成，它们连接在复杂的网络中。这些神经元有两种主要类型--兴奋性和抑制性--它们在平衡中工作。太多的兴奋和大脑成为癫痫，太多的抑制和我们进入昏迷。该建议侧重于特定抑制细胞类型在调节脑功能中的作用，并与从癫痫到精神分裂症再到抑郁症的一系列神经系统疾病有关。