Regulation of cortical excitability by GABAB receptors

GABAB 受体对皮质兴奋性的调节

• 批准号: nhmrc : 1009425
• 负责人: Prof Greg Stuart
• 金额: $ 22.74万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-cortical-excitability-gabab-receptors/109408
• 关键词: Regulation; cortical; excitability; GABAB; receptors

In the brain electrical activity either excites or inhibits nerve cells. Excitation is balanced by inhibition. If these two processes become unbalanced we can become unconscious or go into seizure. These extreme conditions emphasize the importance of the balance between excitation and inhibition in the brain. While there has been much work on the role of excitation, less is known about inhibition. In this project proposal we will investigate how inhibition regulates excitation in the cortex.

在大脑中，电活动要么兴奋，要么抑制神经细胞。兴奋与抑制相平衡。如果这两个过程变得不平衡，我们可能会变得无意识或癫痫发作。这些极端条件强调了大脑中兴奋和抑制之间平衡的重要性。虽然有很多关于兴奋作用的研究，但对抑制作用的了解却很少。在这个项目提案中，我们将研究抑制如何调节皮层的兴奋。