Investigating action potential initiation and propagation in neurons using voltage-sensitive dyes

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Nerve impulses, or action potentials, are the fundamental electrical signals used by the nervous system for communication. Critical to an understanding of neuronal function is the knowledge of where these events are initiated and how they propagate. Furthermore, this knowledge is required for understanding what goes wrong under conditions where there is a disturbance in neuronal communication, as occurs in many neurological disorders such as multiple sclerosis and epilepsy.