Properties of dendritic spines and their role in synaptic plasticity

树突棘的特性及其在突触可塑性中的作用

• 批准号: nhmrc : 585505
• 负责人: Prof Greg Stuart
• 金额: $ 22.46万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/properties-dendritic-spines-synaptic-plasticity/78285
• 关键词: Properties; dendritic; spines; their; role

Connections between nerve cells in the brain often occur onto enlarged protrusions called dendritic spines. This proposal will investigate the properties of dendritic spines, and relate differences in spine properties to synaptic plasticity. This information can be used to better understand and treat neurological disorders associated with spine malfunction, as occur in some forms of mental retardation, and may help with understanding the memory loss that occurs during ageing and dementia.

大脑中神经细胞之间的连接通常发生在称为树突棘的扩大突起上。本计画将探讨树突棘的特性，并将棘特性的差异与突触可塑性联系起来。这些信息可用于更好地了解和治疗与脊柱功能障碍相关的神经系统疾病，如某些形式的智力迟钝，并可能有助于了解衰老和痴呆期间发生的记忆丧失。