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EXAFS CHARACTERIZATION OF LANTHANUM DEPOSITS IN HUMAN LYMPH TISSUE

EXAFS CHARACTERIZATION OF LANTHANUM DEPOSITS IN HUMAN LYMPH TISSUE
人体淋巴组织中镧沉积物的 EXAFS 表征
批准号:
8170258
负责人:
SIMON J GEORGE
金额:
$0.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-02-28

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate is an oral phosphate binder widely used in cases of kidney failure as precipitated lanthanum phosphate remains in the gut and significant lanthanum is not thought to not cross the gut wall. Very recently, one of us has observed La deposits in human lymph tissue present in macrophages. The chemical nature of these deposits is unclear, however, their presence has clear implications for the safety of LaCO3 therapy. We seek to use EXAFS (together with micro-imaging) to structurally characterize these deposits in fixed tissue samples. Understanding the chemical nature of these deposits has clear importance in re-evaluating the health risks associated with lanthanum therapy.
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X-RAY MICROSCOPY AND X-RAY MICRODIFFRACTION OF LANTHANUM DEPOSITS IN NEPHROTIC T
  • 批准号:
    8362306
  • 项目类别:
  • 资助金额:
    $0.14万
  • 财政年份:
    2011
  • 负责人:
    SIMON J GEORGE
  • 依托单位:
X-RAY IMAGING AND XAS SPECTROSCOPIC STUDIES OF GD DEPOSITS ASSOCIATED WITH NSF
  • 批准号:
    8362327
  • 项目类别:
  • 资助金额:
    $0.74万
  • 财政年份:
    2011
  • 负责人:
    SIMON J GEORGE
  • 依托单位:
X-RAY IMAGING AND XAS SPECTROSCOPIC STUDIES OF GD DEPOSITS ASSOCIATED WITH NSF
  • 批准号:
    8170331
  • 项目类别:
  • 资助金额:
    $0.03万
  • 财政年份:
    2010
  • 负责人:
    SIMON J GEORGE
  • 依托单位:
X-RAY MICROSCOPY AND X-RAY MICRODIFFRACTION OF GADOLINIUM DEPOSITS IN NEPHROTIC
  • 批准号:
    8170308
  • 项目类别:
  • 资助金额:
    $0.2万
  • 财政年份:
    2010
  • 负责人:
    SIMON J GEORGE
  • 依托单位: