EXAFS CHARACTERIZATION OF LANTHANUM DEPOSITS IN HUMAN LYMPH TISSUE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 碳酸镧是一种广泛用于肾衰竭病例的口服磷酸盐结合剂，因为沉淀的磷酸镧保留在肠道中，并且认为显著的镧不会穿过肠壁。 最近，我们中的一个人观察到La沉积在人类淋巴组织中存在于巨噬细胞中。 这些沉积物的化学性质尚不清楚，但是，它们的存在对LaCO 3治疗的安全性有明确的影响。我们试图使用EXAFS（连同显微成像），在结构上表征这些存款在固定的组织样本。了解这些沉积物的化学性质对于重新评估与镧治疗相关的健康风险具有明显的重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate is an oral phosphate binder widely used in cases of kidney failure as precipitated lanthanum phosphate remains in the gut and significant lanthanum is not thought to not cross the gut wall. Very recently, one of us has observed La deposits in human lymph tissue present in macrophages. The chemical nature of these deposits is unclear, however, their presence has clear implications for the safety of LaCO3 therapy. We seek to use EXAFS (together with micro-imaging) to structurally characterize these deposits in fixed tissue samples. Understanding the chemical nature of these deposits has clear importance in re-evaluating the health risks associated with lanthanum therapy.