EXAFS CHARACTERIZATION OF LANTHANUM DEPOSITS IN HUMAN LYMPH TISSUE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 碳酸镧是一种口服磷酸盐结合剂，广泛用于肾衰竭的病例，因为沉淀的磷酸镧残留在肠道中，而重要的镧被认为不会穿过肠壁。最近，我们中的一位观察到了巨噬细胞中存在的人类淋巴组织中的La沉淀。这些沉积物的化学性质尚不清楚，然而，它们的存在对LaCO3治疗的安全性具有明显的影响。我们寻求使用EXAFS(结合显微成像)来对固定组织样本中的这些沉积进行结构表征。了解这些沉积物的化学性质对于重新评估与镧治疗相关的健康风险具有明显的重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate is an oral phosphate binder widely used in cases of kidney failure as precipitated lanthanum phosphate remains in the gut and significant lanthanum is not thought to not cross the gut wall. Very recently, one of us has observed La deposits in human lymph tissue present in macrophages. The chemical nature of these deposits is unclear, however, their presence has clear implications for the safety of LaCO3 therapy. We seek to use EXAFS (together with micro-imaging) to structurally characterize these deposits in fixed tissue samples. Understanding the chemical nature of these deposits has clear importance in re-evaluating the health risks associated with lanthanum therapy.