EXAFS CHARACTERIZATION OF LANTHANUM DEPOSITS IN HUMAN LYMPH TISSUE

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 碳酸镧是一种口服磷酸盐结合剂，广泛用于肾衰竭病例，因为沉淀的磷酸镧保留在肠道中，并且不认为大量的镧不会穿过肠壁。 最近，我们之一观察到巨噬细胞中人体淋巴组织中存在 La 沉积物。 这些沉积物的化学性质尚不清楚，但它们的存在对 LaCO3 治疗的安全性具有明显的影响。我们寻求使用 EXAFS（与显微成像一起）对固定组织样本中的这些沉积物进行结构表征。了解这些沉积物的化学性质对于重新评估与镧疗法相关的健康风险具有明显的重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate is an oral phosphate binder widely used in cases of kidney failure as precipitated lanthanum phosphate remains in the gut and significant lanthanum is not thought to not cross the gut wall. Very recently, one of us has observed La deposits in human lymph tissue present in macrophages. The chemical nature of these deposits is unclear, however, their presence has clear implications for the safety of LaCO3 therapy. We seek to use EXAFS (together with micro-imaging) to structurally characterize these deposits in fixed tissue samples. Understanding the chemical nature of these deposits has clear importance in re-evaluating the health risks associated with lanthanum therapy.