X-RAY MICROSCOPY AND X-RAY MICRODIFFRACTION OF LANTHANUM DEPOSITS IN NEPHROTIC T

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 碳酸镧（LaCO 3）是一种口服磷酸盐结合剂，广泛用于终末期肾病（ESRD）。临床前动物研究报告肠外的最高La浓度在肠系膜淋巴结中。我们在给予LaCO 3后尸检时，在肠系膜淋巴结中观察到了以前未报道的La沉积，该沉积通过光学显微镜可见，并通过扫描电子显微镜和能量色散X射线光谱法得到证实。虽然一般认为LaCO 3的吸收最低，但这一演示表明需要进一步研究这种吸收的程度和潜在影响。 为此，将使用微探针测量样品以检查La分布的程度和各种沉积物的化学形式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Lanthanum carbonate (LaCO3) is an oral phosphate binder widely used in end-stage renal disease (ESRD). Preclinical animal studies reported the highest La concentrations outside the gut to be in mesenteric lymph nodes. We observed previously unreported La deposition visible by light microscopy and confirmed by scanning electron microscopy with energy dispersive x-ray spectroscopy in a mesenteric lymph node at autopsy following LaCO3 administration. Although LaCO3 is generally thought to be minimally absorbed, this demonstration suggests the need for further investigation of the extent and potential effects of such absorption. To this end samples will be measured using the microprobe to examine the extent of La distribution and the chemical forms of various deposits.