X-RAY MICROSCOPY AND X-RAY MICRODIFFRACTION OF LANTHANUM DEPOSITS IN NEPHROTIC T

肾病 T 中镧沉积物的 X 射线显微镜和 X 射线微衍射

• 批准号: 8170310
• 负责人: SIMON J GEORGE
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170310
• 关键词: Animals; Autopsy; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Deposition; End stage renal failure; Funding; Grant; Institution; Investigation; Lanthanum; Measures; Mesentery; Microscopy; Oral; Reporting; Research; Research Personnel; Resources; Sampling; Scanning Electron Microscopy; Source; Spectrum Analysis; United States National Institutes of Health; Visible Radiation; absorption; inorganic phosphate; lanthanum carbonate; light microscopy; lymph nodes; pre-clinical

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate (LaCO3) is an oral phosphate binder widely used in end-stage renal disease (ESRD). Preclinical animal studies reported the highest La concentrations outside the gut to be in mesenteric lymph nodes. We observed previously unreported La deposition visible by light microscopy and confirmed by scanning electron microscopy with energy dispersive x-ray spectroscopy in a mesenteric lymph node at autopsy following LaCO3 administration. Although LaCO3 is generally thought to be minimally absorbed, this demonstration suggests the need for further investigation of the extent and potential effects of such absorption. To this end samples will be measured using the microprobe to examine the extent of La distribution and the chemical forms of various deposits.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 碳酸镧(LaCO3)是一种口服磷酸盐结合剂，广泛用于终末期肾病(ESRD)。临床前动物研究报告了肠道外La浓度最高的是肠系膜淋巴结。我们在给LaCO3后的尸检中观察到了以前未报道过的La沉积，并通过扫描电子显微镜和能量色散X射线光谱分析证实了这一点。虽然一般认为LaCO3被最低限度地吸收，但这一证明表明有必要对这种吸收的程度和潜在影响进行进一步调查。为此，将使用微型探头测量样品，以检查La的分布范围和各种沉积物的化学形态。