X-RAY IMAGING AND XAS SPECTROSCOPIC STUDIES OF GD DEPOSITS ASSOCIATED WITH NSF

与 NSF 相关的 GD 矿床的 X 射线成像和 XAS 光谱研究

• 批准号: 8170331
• 负责人: SIMON J GEORGE
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170331
• 关键词: Autopsy; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Deposition; Diagnostic radiologic examination; Disease; Exposure to; Fibrosis; Freezing; Funding; Gadolinium; Grant; Image; Individual; Institution; Kidney Failure; Magnetic Resonance Imaging; Nature; Pain; Patients; Play; Process; Publications; Research; Research Personnel; Resources; Role; Skin; Source; Spectrum Analysis; Structure; Symptoms; Time; Tissue Sample; Tissues; United States National Institutes of Health; Work; base; inorganic phosphate; particle; tissue fixing; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nephrotic systemic fibrosis (NSF) is a debilitating, painful, often fatal disease. It is associated with renal insufficiency and exposure to gadolinium-based magnetic resonance imaging contrast agents. Symptoms include the presence of insoluble Gadolinium deposits in the skin. It is believed that these deposits may play a key role in the NSF disease. However, their chemical composition is currently unclear. Resolving this is clearly important for a proper understanding of the disease. We have previously characterized a fixed autopsy tissue sample using micro XAS imaging, x-ray tomography and EXAFS spectroscopy. These results show a distribution of Gd:Ca:P particles with a structure based on gadolinium phosphate. This work has been submitted for publication. We plan to extend these studies to fixed and frozen tissue samples from several different patients and from the same patient at different times. This will also us to characterize detailed differences and changes in the structure of the Gd deposits with different patients and with an individual patient?s disease status. Comparisons of fixed and frozen tissues will confirm whether the process of fixing the tissue has chemically modified the deposits. Frozen tissue samples will also allow study the chemical nature of any Gd outside the insoluble deposits.

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