X-RAY MICROSCOPY AND X-RAY MICRODIFFRACTION OF GADOLINIUM DEPOSITS IN NEPHROTIC

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 碳酸镧(LaCO3)是一种口服磷酸盐结合剂，广泛用于终末期肾病(ESRD)。临床前动物研究报告了肠道外La浓度最高的是肠系膜淋巴结。我们在一例38岁女性终末期肾病患者的尸检中观察到了以前未见报道的La沉积，在给药3年后，通过扫描电子显微镜和能量色散X射线光谱分析证实了这一点。虽然一般认为LaCO3被最低限度地吸收，但这一证明表明有必要对这种吸收的程度和潜在影响进行进一步调查。为此，将在SSRL使用BL2-3处的微探针测量样品，以检查La和Ga的分布范围和沉积物的化学形态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate (LaCO3) is an oral phosphate binder widely used in end-stage renal disease (ESRD). Preclinical animal studies reported the highest La concentrations outside the gut to be in mesenteric lymph nodes. We observed previously unreported La deposition visible by light microscopy and confirmed by scanning electron microscopy with energy dispersive x-ray spectroscopy in a mesenteric lymph node at autopsy of a 38-year-old female ESRD patient 3 years following LaCO3 administration. Although LaCO3 is generally thought to be minimally absorbed, this demonstration suggests the need for further investigation of the extent and potential effects of such absorption. To this end samples will be measured using the microprobe at BL 2-3 at SSRL to examine the extent of La and Ga distribution and the chemical forms of the deposits.