X-RAY MICROSCOPY AND X-RAY MICRODIFFRACTION OF GADOLINIUM DEPOSITS IN NEPHROTIC

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 碳酸镧（LaCO 3）是一种口服磷酸盐结合剂，广泛用于终末期肾病（ESRD）。临床前动物研究报告肠外的最高La浓度在肠系膜淋巴结中。我们观察到以前未报告的镧沉积可见光显微镜和证实的扫描电子显微镜与能量色散X-射线光谱在肠系膜淋巴结尸检的一名38岁女性ESRD患者3年后，碳酸镧管理。虽然一般认为LaCO 3的吸收最低，但这一演示表明需要进一步研究这种吸收的程度和潜在影响。 为此，将使用SSRL BL 2-3的微探针测量样品，以检查La和Ga分布的程度以及沉积物的化学形式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lanthanum carbonate (LaCO3) is an oral phosphate binder widely used in end-stage renal disease (ESRD). Preclinical animal studies reported the highest La concentrations outside the gut to be in mesenteric lymph nodes. We observed previously unreported La deposition visible by light microscopy and confirmed by scanning electron microscopy with energy dispersive x-ray spectroscopy in a mesenteric lymph node at autopsy of a 38-year-old female ESRD patient 3 years following LaCO3 administration. Although LaCO3 is generally thought to be minimally absorbed, this demonstration suggests the need for further investigation of the extent and potential effects of such absorption. To this end samples will be measured using the microprobe at BL 2-3 at SSRL to examine the extent of La and Ga distribution and the chemical forms of the deposits.