UNDERSTANDING RNA DIRECTED RNA POLYMERASES
UNDERSTANDING RNA DIRECTED RNA POLYMERASES
批准号:
8170279
负责人:
David A. Bushnell
金额:
$0.34万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-02-28
关键词:
Antiviral AgentsCommon ColdComputer Retrieval of Information on Scientific Projects DatabaseExhibitsFingersFundingGrantHandHepatitis C virusInstitutionPolymeraseRNA-Directed RNA PolymeraseResearchResearch PersonnelResourcesRhinovirusSourceStructureThumb structureUnited States National Institutes of Healthviral RNA
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
RNA-dependent RNA polymerases are commonly found in pathogenic viruses from Hepatitis C (HCV) to the common cold (rhinovirus). Structures of RNA-dependent RNA polymerases show a remarkable amount of conservation exhibiting an overall fold with three major domains (palm, fingers and thumb) arranged like a right hand. This strong structural conservation makes viral RNA-dependent RNA polymerases a compelling target for antiviral compounds. Our research focuses on understanding how RNA-dependent RNA polymerases function in order to rationally develop broad acting antiviral compounds.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
STRUCTURAL STUDIES OF THE EUKARYOTIC TRANSCRIPTION MACHINERY
-
批准号:8362149
-
项目类别:
-
资助金额:$1.56万
-
财政年份:2011
-
负责人:David A. Bushnell
-
依托单位:
UNDERSTANDING RNA DIRECTED RNA POLYMERASES
-
批准号:8362278
-
项目类别:
-
资助金额:$1.04万
-
财政年份:2011
-
负责人:David A. Bushnell
-
依托单位:
ARCHITECTURE OF THE EUKARYOTIC TRANSCRIPTION APPARATUS IN SOLUTION
-
批准号:8170044
-
项目类别:
-
资助金额:$0.34万
-
财政年份:2010
-
负责人:David A. Bushnell
-
依托单位:
STRUCTURAL STUDIES OF THE EUKARYOTIC TRANSCRIPTION MACHINERY
-
批准号:8170090
-
项目类别:
-
资助金额:$1.76万
-
财政年份:2010
-
负责人:David A. Bushnell
-
依托单位:
ARCHITECTURE OF THE EUKARYOTIC TRANSCRIPTION APPARATUS IN SOLUTION
-
批准号:7954368
-
项目类别:
-
资助金额:$0.21万
-
财政年份:2009
-
负责人:David A. Bushnell
-
依托单位:
STRUCTURAL STUDIES OF THE EUKARYOTIC TRANSCRIPTION MACHINERY
-
批准号:7954417
-
项目类别:
-
资助金额:$0.95万
-
财政年份:2009
-
负责人:David A. Bushnell
-
依托单位:
STRUCTURAL STUDIES OF THE EUKARYOTIC TRANSCRIPTION MACHINERY
-
批准号:7722108
-
项目类别:
-
资助金额:$0.06万
-
财政年份:2008
-
负责人:David A. Bushnell
-
依托单位:
INITIAL SOLUTION X-RAY SCATTERING STUDIES ON RNA POLYMERASE II-TBP-TFIIB-TFIIF-P
-
批准号:7722076
-
项目类别:
-
资助金额:$0.08万
-
财政年份:2008
-
负责人:David A. Bushnell
-
依托单位:
ARCHITECTURE OF THE EUKARYOTIC TRANSCRIPTION APPARATUS IN SOLUTION
-
批准号:7722029
-
项目类别:
-
资助金额:$0.13万
-
财政年份:2008
-
负责人:David A. Bushnell
-
依托单位:
THE STRUCTURE OF RNA POLYMERASE II AND ASSOCIATED FACTORS
-
批准号:7721737
-
项目类别:
-
资助金额:$0.52万
-
财政年份:2008
-
负责人:David A. Bushnell
-
依托单位:
海外基金