UNDERSTANDING RNA DIRECTED RNA POLYMERASES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 RNA依赖的RNA聚合酶普遍存在于从丙型肝炎(丙型肝炎)到普通感冒(鼻病毒)的致病病毒中。依赖RNA的RNA聚合酶的结构显示出显著的保守量，表现出三个主要结构域(手掌、手指和拇指)像右手一样排列的整体折叠。这种强大的结构保守性使病毒RNA依赖的RNA聚合酶成为抗病毒化合物的引人注目的靶标。我们的研究重点是了解依赖RNA的RNA聚合酶的功能，以便合理地开发广泛作用的抗病毒化合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. RNA-dependent RNA polymerases are commonly found in pathogenic viruses from Hepatitis C (HCV) to the common cold (rhinovirus). Structures of RNA-dependent RNA polymerases show a remarkable amount of conservation exhibiting an overall fold with three major domains (palm, fingers and thumb) arranged like a right hand. This strong structural conservation makes viral RNA-dependent RNA polymerases a compelling target for antiviral compounds. Our research focuses on understanding how RNA-dependent RNA polymerases function in order to rationally develop broad acting antiviral compounds.