UNDERSTANDING RNA DIRECTED RNA POLYMERASES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 RNA依赖性RNA聚合酶通常存在于从丙型肝炎（HCV）到普通感冒（鼻病毒）的致病病毒中。 RNA依赖性RNA聚合酶的结构显示出显著的保守性，表现出具有三个主要结构域（手掌、手指和拇指）的整体折叠，如右手一样排列。 这种强的结构保守性使得病毒RNA依赖性RNA聚合酶成为抗病毒化合物的引人注目的靶标。 我们的研究重点是了解RNA依赖性RNA聚合酶的功能，以合理开发广泛作用的抗病毒化合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. RNA-dependent RNA polymerases are commonly found in pathogenic viruses from Hepatitis C (HCV) to the common cold (rhinovirus). Structures of RNA-dependent RNA polymerases show a remarkable amount of conservation exhibiting an overall fold with three major domains (palm, fingers and thumb) arranged like a right hand. This strong structural conservation makes viral RNA-dependent RNA polymerases a compelling target for antiviral compounds. Our research focuses on understanding how RNA-dependent RNA polymerases function in order to rationally develop broad acting antiviral compounds.