UNDERSTANDING RNA DIRECTED RNA POLYMERASES

了解 RNA 定向 RNA 聚合酶

• 批准号: 8362278
• 负责人: David A. Bushnell
• 金额: $ 1.04万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362278
• 关键词: Antiviral Agents; Common Cold; Exhibits; Fingers; Funding; Grant; Hand; Hepatitis C virus; National Center for Research Resources; Principal Investigator; RNA; RNA Polymerase I; RNA-Directed RNA Polymerase; Radiation; Research; Research Infrastructure; Resources; Rhinovirus; Source; Structure; Thumb structure; United States National Institutes of Health; cost; structural biology; viral RNA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. RNA-dependent RNA polymerases are commonly found in pathogenic viruses from Hepatitis C (HCV) to the common cold (rhinovirus). Structures of RNA-dependent RNA polymerases show a remarkable amount of conservation exhibiting an overall fold with three major domains (palm, fingers and thumb) arranged like a right hand. This strong structural conservation makes viral RNA-dependent RNA polymerases a compelling target for antiviral compounds. Our research focuses on understanding how RNA-dependent RNA polymerases function in order to rationally develop broad acting antiviral compounds.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 RNA 依赖性 RNA 聚合酶常见于从丙型肝炎 (HCV) 到普通感冒（鼻病毒）的致病病毒中。 RNA依赖性RNA聚合酶的结构显示出显着的保守性，表现出整体折叠，三个主要结构域（手掌、手指和拇指）排列得像右手。 这种强大的结构保守性使得病毒 RNA 依赖性 RNA 聚合酶成为抗病毒化合物的引人注目的靶标。 我们的研究重点是了解 RNA 依赖性 RNA 聚合酶如何发挥作用，以便合理开发广泛作用的抗病毒化合物。