SYNTHESIS OF DOPA-MODIFIED PEG

多巴修饰 PEG 的合成

• 批准号: 8168935
• 负责人: B Craig Lee
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168935
• 关键词: Adhesions; Adhesives; Amino Acids; Area; Bacteria; Binding; Biocompatible; Biocompatible Coated Materials; Cells; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Dopa; Environment; Funding; Goals; Grant; Institution; Marines; Medical; Metals; Mussels; Polymers; Proteins; Research; Research Personnel; Resistance; Resources; Safety; Semiconductors; Source; Surface; Tissue Adhesives; United States National Institutes of Health; Water; aqueous; design; improved; interfacial; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Marine mussels are known to anchor themselves to underwater surfaces in turbulent intertidal zones. They secrete adhesive proteins that can rapidlycure to form adhesive plaques. It is believed that3,4-dihydroxyphenylalanine (DOPA), an amino acid found in MAPs at a contentas much as 25 mol%, is responsible for both strong interfacial binding and curing of these proteins. The goals of our research are to combine the water-resistant adhesive characteristics of DOPA and its derivatives with biocompatible, synthetic polymer for different biomedical applications. One aspect of our research is to design DOPA-modified polymers for the use as tissue adhesive or sealant, which exploits DOPA's ability to cure rapidly and to adhere to a wide variety of surfaces in an aqueous environment. Through the use of different synthetic polymers, it is possible to create novel bioadhesives with improved characteristics (i.e. water-resistant adhesion, biodegradability, and safety) as compared to existing medical adhesives. Another research area focuses on combining DOPA with antifouling polymers to create coating materials that can repel proteins, cells, and bacteria. These coatings can render different surfaces resistant to cell and bacteria adhesion ranging from metals, semiconductors, and synthetic polymers.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 众所周知，海洋贻贝会将自己锚定在湍急的潮间带的水下表面。它们分泌的粘附蛋白可以快速固化形成粘附斑块。 据信，3,4-二羟基苯丙氨酸（DOPA）是一种在 MAP 中含量高达 25 mol% 的氨基酸，它负责这些蛋白质的强界面结合和固化。 我们研究的目标是将多巴及其衍生物的防水粘合剂特性与生物相容性合成聚合物结合起来，用于不同的生物医学应用。 我们研究的一方面是设计用作组织粘合剂或密封剂的多巴改性聚合物，它利用了多巴快速固化并在水性环境中粘附到各种表面的能力。通过使用不同的合成聚合物，可以创造出与现有医用粘合剂相比具有改进特性（即防水粘合性、生物可降解性和安全性）的新型生物粘合剂。 另一个研究领域侧重于将多巴与防污聚合物相结合，创造出可以排斥蛋白质、细胞和细菌的涂层材料。 这些涂层可以使不同的表面抵抗细胞和细菌的粘附，包括金属、半导体和合成聚合物。