SYNTHESIS OF DOPA-MODIFIED PEG

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 已知海洋贻贝在湍流潮间带中将自身锚在水下表面。它们分泌的粘附蛋白能迅速固化形成粘附斑块。 据信，3，4-二羟基苯丙氨酸（DOPA），一种在MAPs中发现的含量高达25mol%的氨基酸，负责这些蛋白质的强界面结合和固化。 我们的研究目标是结合联合收割机的多巴及其衍生物与生物相容性，合成聚合物的耐水粘合特性，用于不同的生物医学应用。 我们研究的一个方面是设计DOPA改性聚合物用作组织粘合剂或密封剂，其利用DOPA快速固化并在水性环境中粘附到各种表面的能力。通过使用不同的合成聚合物，与现有的医用粘合剂相比，可以产生具有改进特性（即防水粘合性、生物降解性和安全性）的新型生物粘合剂。 另一个研究领域的重点是将DOPA与可降解聚合物相结合，以创建可以排斥蛋白质，细胞和细菌的涂层材料。 这些涂层可以使不同的表面抵抗细胞和细菌粘附，范围从金属，半导体和合成聚合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Marine mussels are known to anchor themselves to underwater surfaces in turbulent intertidal zones. They secrete adhesive proteins that can rapidlycure to form adhesive plaques. It is believed that3,4-dihydroxyphenylalanine (DOPA), an amino acid found in MAPs at a contentas much as 25 mol%, is responsible for both strong interfacial binding and curing of these proteins. The goals of our research are to combine the water-resistant adhesive characteristics of DOPA and its derivatives with biocompatible, synthetic polymer for different biomedical applications. One aspect of our research is to design DOPA-modified polymers for the use as tissue adhesive or sealant, which exploits DOPA's ability to cure rapidly and to adhere to a wide variety of surfaces in an aqueous environment. Through the use of different synthetic polymers, it is possible to create novel bioadhesives with improved characteristics (i.e. water-resistant adhesion, biodegradability, and safety) as compared to existing medical adhesives. Another research area focuses on combining DOPA with antifouling polymers to create coating materials that can repel proteins, cells, and bacteria. These coatings can render different surfaces resistant to cell and bacteria adhesion ranging from metals, semiconductors, and synthetic polymers.