STRUCTURE OF POTASSIUM CHANNELS

钾通道的结构

• 批准号: 8169253
• 负责人: RODERICK MACKINNON
• 金额: $ 2.09万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169253
• 关键词: Asthma; Atrial Fibrillation; Blood Vessels; Computer Retrieval of Information on Scientific Projects Database; Funding; G-Protein Signaling Pathway; GTP-Binding Proteins; Grant; Heart Rate; Institution; Ion Channel; Membrane; Membrane Potentials; Molecular Conformation; Neurons; Potassium Channel; Process; Property; Research; Research Personnel; Resources; Rest; Signal Transduction; Source; Structure; United States National Institutes of Health; brain cell; cell type; hypertension treatment; inward rectifier potassium channel; respiratory smooth muscle; response; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research at NECAT aims to decipher the gating mechanisms and pharmacological properties of various eukaryotic K+ ion channels. The first channel is the voltage-dependent K+ channel, which opens in response to changes in membrane voltage and is responsible for producing electrical signals in brain cells. We are aiming to determine structures of intermediate gating states to understand how membrane voltage drives the channel between closed and opened conformations. The second channel is the eukaryotic inward rectifier K+ channel, which controls the resting membrane potential in many neurons. The third channel is the G-protein-gated channel, which opens in response to the stimulation of G-proteins signaling pathways. This channel type regulates heart rate, among other processes, and is an important potential target for the treatment of atrial fibrillation. The fourth channel is the high-condcutance Ca2+ and voltage-dependent K+ channel. This channel functions in various cell types, including vascular and airway smooth muscle. It is a potential target for the treatment of hypertension and asthma.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们在NECAT的研究旨在破译各种真核K+离子通道的门控机制和药理学特性。第一个通道是电压依赖性K+通道，其响应于膜电压的变化而打开，并负责在脑细胞中产生电信号。我们的目标是确定中间门控状态的结构，以了解膜电压如何驱动关闭和打开构象之间的通道。第二个通道是真核细胞内向整流K+通道，它控制许多神经元的静息膜电位。第三个通道是G蛋白门控通道，其响应于G蛋白信号通路的刺激而打开。该通道类型调节心率，以及其他过程，并且是治疗房颤的重要潜在靶点。第四个通道是高电导Ca ~（2+）和电压依赖性K ~+通道。该通道在各种细胞类型中起作用，包括血管和气道平滑肌。它是治疗高血压和哮喘的潜在靶点。