RAP PHOSPHATASES
RAP PHOSPHATASES
批准号:
8170606
负责人:
Matthew B Neiditch
金额:
$0.41万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2011-06-30
关键词:
Bacillus subtilisBacteriaBindingBiochemical GeneticsCell Signaling ProcessCellsCompetenceComplexComputer Retrieval of Information on Scientific Projects DatabaseCrystallographyDNADevelopmentFamilyFundingGene ExpressionGeneticGrantInstitutionPeptidesPhosphoric Monoester HydrolasesProteinsResearchResearch PersonnelResourcesRoentgen RaysSignal TransductionSignal Transduction PathwaySourceStructureTimeUnited States National Institutes of Healthpreventpromoterprotein functionquorum sensing
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Quorum sensing is a bacterial cell-cell communication process that allows groups of bacteria to act in unison, synchronizing important phenotypic changes. One family of secreted quorum-sensing signals, called Phr pentapeptides, is imported into the cell where they inhibit the activity of proteins called Raps. To determine how Rap proteins function mechanistically, and how Rap functions are in turn regulated by Phr peptides, we are studying two subsets of Bacillus subtilis Rap proteins. One Rap protein subset negatively regulates sporulation in B. subtilis by dephosphorylating a central protein in the sporulation signal transduction pathway, the other subset of Rap proteins downregulates the development of genetic competence by preventing the master transcriptional regulator of early competence gene expression from binding to target DNA promoters. We have crystallized Rap proteins in complex with their target effector proteins, as well as with their regulatory Phr peptides. The X-ray crystal structures of these complexes, combined with biochemical and genetic studies, will reveal for the first time how Rap proteins function mechanistically and how Phr peptides regulate Rap protein activity.
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会议论文
The contribution of novel cytidine deaminase regulatory systems to bacterial evolution
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批准号:10553666
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项目类别:
-
资助金额:$57.31万
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财政年份:2021
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负责人:Matthew B Neiditch
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依托单位:
The contribution of novel cytidine deaminase regulatory systems to bacterial evolution
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批准号:10179834
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项目类别:
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资助金额:$59.37万
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财政年份:2021
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负责人:Matthew B Neiditch
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依托单位:
The contribution of novel cytidine deaminase regulatory systems to bacterial evolution
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批准号:10339467
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项目类别:
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资助金额:$57.87万
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财政年份:2021
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负责人:Matthew B Neiditch
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依托单位:
X-ray Crystallographic Analysis of Diguanylate Cyclase Enzyme-Inhibitor Complexes
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批准号:8582834
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项目类别:
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资助金额:$0.53万
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财政年份:2013
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负责人:Matthew B Neiditch
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依托单位:
X-ray Crystallographic Analysis of Diguanylate Cyclase Enzyme-Inhibitor Complexes
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批准号:8712661
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项目类别:
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资助金额:$7.42万
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财政年份:2013
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负责人:Matthew B Neiditch
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依托单位:
Structural Biology of Multifunctional Bacterial Phosphatases
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批准号:7631902
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项目类别:
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资助金额:$39.0万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
Structural Biology of Multifunctional Bacterial Phosphatases
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批准号:8711660
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项目类别:
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资助金额:$12.55万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
HOLOLUXP:LUXQ
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批准号:7957300
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项目类别:
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资助金额:$0.48万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
Structural Biology of Multifunctional Bacterial Phosphatases
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批准号:8117171
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项目类别:
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资助金额:$38.22万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
RAP PHOSPHATASES
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批准号:7957284
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项目类别:
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资助金额:$1.0万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
Structural Biology of Multifunctional Bacterial Phosphatases
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批准号:8306792
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项目类别:
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资助金额:$25.92万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
Structural Biology of Multifunctional Bacterial Phosphatases
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批准号:7900858
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项目类别:
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资助金额:$38.61万
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财政年份:2009
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负责人:Matthew B Neiditch
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依托单位:
HOLOLUXP:LUXQ
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批准号:7358954
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项目类别:
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资助金额:$0.29万
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财政年份:2006
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负责人:Matthew B Neiditch
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依托单位:
HOLO LUXP:LUXQ
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批准号:7182509
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项目类别:
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资助金额:$0.56万
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财政年份:2005
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负责人:Matthew B Neiditch
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依托单位:
Structural Analysis of Bacterial Quorum Sensing Proteins
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批准号:6886573
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项目类别:
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资助金额:$4.83万
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财政年份:2005
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负责人:Matthew B Neiditch
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依托单位:
Structural Analysis of Bacterial Quorum Sensing Proteins
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批准号:7024483
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项目类别:
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资助金额:$5.04万
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财政年份:2005
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负责人:Matthew B Neiditch
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依托单位:
国内基金
海外基金
Segmented Filamentous Bacteria激活宿主免疫系统抑制其拮抗菌 Enterobacteriaceae维持菌群平衡及其机制研究
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批准号:81971557
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项目类别:面上项目
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资助金额:65.0万元
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批准年份:2019
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负责人:毛开睿
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依托单位:
电缆细菌(Cable bacteria)对水体沉积物有机污染的响应与调控机制
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批准号:51678163
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项目类别:面上项目
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资助金额:64.0万元
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批准年份:2016
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负责人:许玫英
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依托单位: