ULTRASOUND SPECKLE TRACKING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 细微的动脉弹性变化可以通过使用商业US探头的体内应变成像和脉搏波速度（PWV）来检测和监测。基于相关的相敏散斑跟踪提供了高达微米尺度的高分辨率的2D应变图。压力均衡在大的动态范围内提供非线性弹性特性估计。结合这两个独立的测量优化的弹性模量重建将消除几何因素和边界效应的不确定性。在常规超声检查中，使用这些新型集成技术可以进行简单的体内弹性模量测量。重建的弹性模量可以清楚地区分健康组（蓝色）和疾病组（红色）。用于克罗恩病的NIH R21申请正在接受行政JIT审查以获得资金。用于组织工程和再生医学的NIH R 01正在申请中。使用线性探头的PWV的美国专利正在申请中（序列号PCT/US 07/021244-于2007年3月10日提交）。正在寻求新的应用，如心脏功能表征，特别是3D弹性成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Subtle arterial elasticity changes can be detected and monitored by in-vivo strain imaging and Pulse Wave Velocity (PWV) using a commercial US probe. Correlation-based phase sensitive speckle tracking provides a 2D strain map with high resolution up to micron scales. Pressure equalization provides non-linear elastic property estimates over a large dynamic range. Optimized elastic modulus reconstruction combining these two independent measurements will remove the uncertainties with geometrical factors and boundary effects. Simple in-vivo elastic modulus measurements can be performed using these novel integrated technologies, during a routine US exam. The reconstructed elastic modulus clearly separates healthy (blue) from disease groups (red). NIH R21 for Crohns disease application is under administrative JIT review for funding. NIH R01 for tissue engineering and regenerative medicine application is in pending. US patent for PWV using linear probe is pending (Serial No. PCT/US07/021244-filed on 10/03/07). New applications such as cardiac function characterization are being sought, especially for 3D elasticity imaging.