ULTRASOUND SPECKLE TRACKING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 微妙的动脉弹性变化可以通过使用商业US探头的体内应变成像和脉搏波速度(PWV)来检测和监测。基于相关性的相敏散斑跟踪提供了高分辨率高达微米级的2D应变图。压力均衡在很大的动态范围内提供了非线性弹性特性估计。结合这两个独立的测量结果，优化的弹性模量值重建将消除几何因素和边界效应的不确定性。在常规的美国检查中，可以使用这些新的集成技术进行简单的体内弹性模数测量。重建的弹性模数清楚地区分了健康组(蓝色)和疾病组(红色)。NIH R21用于克罗恩斯病的申请正在接受行政JIT审查，以获得资金。NIH R01用于组织工程和再生医学的应用正在进行中。使用线性探头的PWV的美国专利正在申请中(序列号PCT/US07/021244-于2007年3月10日提交)。人们正在寻求新的应用，如心脏功能表征，特别是3D弹性成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Subtle arterial elasticity changes can be detected and monitored by in-vivo strain imaging and Pulse Wave Velocity (PWV) using a commercial US probe. Correlation-based phase sensitive speckle tracking provides a 2D strain map with high resolution up to micron scales. Pressure equalization provides non-linear elastic property estimates over a large dynamic range. Optimized elastic modulus reconstruction combining these two independent measurements will remove the uncertainties with geometrical factors and boundary effects. Simple in-vivo elastic modulus measurements can be performed using these novel integrated technologies, during a routine US exam. The reconstructed elastic modulus clearly separates healthy (blue) from disease groups (red). NIH R21 for Crohns disease application is under administrative JIT review for funding. NIH R01 for tissue engineering and regenerative medicine application is in pending. US patent for PWV using linear probe is pending (Serial No. PCT/US07/021244-filed on 10/03/07). New applications such as cardiac function characterization are being sought, especially for 3D elasticity imaging.